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CBD for Pain Following Orthopedic Shoulder Surgery

Cannabis News
CED Clinical Relevanceย ย #92High Clinical Relevanceย ย Strong evidence or policy relevance with direct clinical implications.
๐Ÿงช Clinical Trial Watchย ย |ย ย CED Clinic
Clinical TrialPost-Operative PainCbdEpidiolexPlacebo-Controlled
Trial ID NCT06381791
Phase N/A
Status Recruiting
Condition Shoulder Osteoarthritis
Intervention Epidiolex
Why This Matters

Post-operative pain management remains a significant challenge, with many patients requiring opioids that carry addiction risks. This trial addresses whether pharmaceutical-grade CBD can serve as an effective adjunct analgesic in the acute post-surgical period, potentially reducing opioid requirements.

Clinical Summary

This placebo-controlled trial is evaluating Epidiolex (pharmaceutical CBD) as adjunctive pain management following orthopedic shoulder surgery in patients with shoulder osteoarthritis. Participants maintain daily pain diaries, undergo weekly researcher check-ins, complete pre- and post-operative surveys, and provide blood samples for pharmacokinetic analysis. The study is currently recruiting and focuses on both efficacy and safety endpoints including optimal dosing parameters.

Dr. Caplan’s Take

โ€œIf positive, this could provide the first rigorous evidence for CBD’s role in acute post-operative pain, giving me a validated tool to potentially reduce my patients’ opioid exposure during their most vulnerable recovery period.โ€

Clinical Perspective
๐Ÿง  Patients considering participation should understand this involves pharmaceutical-grade CBD, not retail products, with careful medical monitoring throughout recovery. Clinicians should note this represents one of the first controlled trials examining CBD specifically for acute surgical pain rather than chronic conditions.

๐Ÿ’ฌ Join the Conversation

Have a question about how this applies to your situation? Ask Dr. Caplan โ†’

Want to discuss this topic with other patients and caregivers? Join the forum discussion โ†’





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