Assessment of clinical outcomes in patients with post-traumatic stress disorder: analysis from the UK Medical Cannabis Registry
Further research is needed to establish the efficacy and safety of cannabis-based medicinal products in treating PTSD, as current evidence is limited.
A Pilot Randomized Placebo-Controlled Crossover Trial of Medicinal Cannabis in Adolescents with Tourette Syndrome
This pilot study indicates that medicinal cannabis may be a feasible treatment option for adolescents with Tourette Syndrome, warranting further investigation in a fully powered trial.
Cannabis and Cannabinoids in Adults With Cancer: ASCO Guideline
Clinicians should consider the use of cannabis and cannabinoids as part of a comprehensive treatment plan for cancer patients, focusing on symptom management and patient quality of life.
A Systematic Review of the Clinical Effects of Cannabis and Cannabinoids in Posttraumatic Stress Disorder Symptoms and Symptom Clusters
While cannabinoids may offer targeted relief for specific PTSD symptoms like nightmares and sleep disturbances (Cluster B and E), current evidence does not support major global improvements in overall PTSD severity. Furthermore, frequent use or concurrent Cannabis Use Disorder (CUD) is strongly linked to worsening symptom trajectories, increased suicidality, and aggressive behaviors, necessitating careful screening and caution in clinical practice.
Cannabis and cannabidiol for postoperative pain management in orthopedic surgery: a scoping review
Current clinical evidence regarding the use of cannabinoids for postoperative pain in orthopedic surgery remains inconclusive due to significant trial heterogeneity and lack of product standardization. While THC/CBD combinations demonstrate modest potential for opioid-sparing effects and CBD shows early short-term promise, clinicians should exercise caution, carefully screen for concurrent substance use, and await standardized prospective trials before implementing routine perioperative cannabinoid protocols.
Medicinal cannabis for symptom control in advanced cancer: a double-blind, placebo-controlled, randomised clinical trial of 1:1 tetrahydrocannabinol and cannabidiol
Researchers followed adults with advanced cancer receiving palliative care to see if a daily plant oil containing equal parts of active cannabis compounds could lower their overall distress. Participants took either the cannabis oil or an identical-looking inactive oil, starting with low amounts and adjusting upwards over four weeks while keeping their usual medical care.
“Does medical cannabis actually treat PTSD? | CED Clinic”
Clinical research indicates that cannabinoids do not "cure" PTSD or reliably lower total PTSD severity scores across the board, but they can offer targeted temporary relief for specific symptom clusters like traumatic nightmares, sleep disruption, and...
“Why does a low dose of cannabis help my anxiety?”
Cannabis compounds often produce what pharmacologists call a "biphasic effect," meaning low doses and higher doses can produce opposite reactions in the body. While a small amount of THC can calm the nervous system and relieve...
“Does medical cannabis help with cancer pain? | CED Clinic”
This is a very tricky question - with answers that keep changing with different papers and patient reports. For overall symptom burden, a recent randomized trial found no benefit beyond good palliative care - both groups...
