CORR Insights®: Does Cannabis-based Medicine Improve Pain and Sleep Quality in Patients With Traumatic Brachial Plexus Injuries? A Triple-blind, Crossover, Randomized Controlled Trial
Researchers evaluated whether adding plant-derived cannabis drops to standard medical treatment would improve chronic nerve pain and sleep for adult men who suffered severe shoulder and arm nerve trauma. The study used a rigorous design where participants received either cannabis or a dummy substance for two weeks before switching treatments.
The Acute Effects of Cannabidiol on Physiological and Subjective Responses to Endurance Exercise: A Dose-Ranging Randomised Controlled Crossover Trial
This study looked at how cannabidiol (CBD), a compound from cannabis plants, affects athletes during endurance exercise. Researchers compared how CBD and a placebo affected athletes' physical responses and how they felt during exercise. The study aimed to see if CBD could help with recovery or performance.
Effects and safety of a CBD-rich Cannabis sativa oil in knee osteoarthritis: a double-blind, randomized, placebo-controlled trial - CANOA - cannabis for osteoarthritis
Researchers in Brazil studied adult patients with painful knee osteoarthritis to see if a daily plant extract oil rich in cannabidiol helped reduce joint pain and improve daily living. Participants took either the cannabis oil or an inactive oil twice a day for two months while keeping their regular doctor-prescribed medications.
Potency-related effects of smoked cannabis on simulated driving performance: a randomized, controlled crossover trial
Researchers in Toronto studied adults who use cannabis regularly and hold driver's licences. Each person sat in a driving simulator after smoking cannabis of different strengths, or a dummy product with no active ingredient, on separate days.
A Systematic Review of Medical Cannabinoids Dosing in Human
Clinicians should consider the diversity of cannabinoids and dosing regimens when evaluating treatment options for patients.
Long-Term Inhaled Cannabis Therapy for Chronic Low Back Pain: A Five-Year Retrospective Analysis of Prospectively Collected Patient-Reported Outcomes in 241 Treatment-Refractory Patients
This study followed 241 adults with long-standing lower back pain that had not improved with usual treatments such as prescription painkillers, nerve medicines, antidepressants, anti-inflammatory tablets and physiotherapy. Each person started a medical cannabis treatment that was mostly smoked, and their progress was tracked once a year for five years.
Cannabis for sleep in older adults: use has outpaced the science
This is a review article about older adults, meaning people aged 50 and up, who use cannabis to help them sleep. The authors looked at what research already exists and what is still missing. They did not run a new study with patients.
Results of an Exploratory Crossover Pharmacokinetic Study Evaluating a Natural Hemp Extract-Based Cosmetic Product: Comparison of Topical and Oral Routes of Administration
Twenty healthy adults took a hemp-derived oil product that contains a substance called cannabidiol, either by mouth or rubbed onto the skin, at different times. Blood was drawn over the following day to see how much of the substance entered the body by each route.
UK Medical Cannabis Registry: An Updated Analysis of Inflammatory Arthritis
This study followed 192 adults in the United Kingdom who had long-lasting pain from arthritis and were given medicinal cannabis by a private clinic. Each person filled in questionnaires about pain, mood, sleep and daily life over two years. The researchers looked at how these answers changed over time.
Studies of Cannabinoid-Based Products in ClinicalTrials.gov: A Scoping Review
This study looked at the list of research projects that have been registered on a public website that tracks medical studies. It counted the cannabis-based treatments being tested, the health problems they aim to address, and how big and how long the studies tend to be.