The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation

In Summary:

​The Importance of Chemical Structure: Functional Groups of Flavonoids

A recent study has revealed the detrimental effects of the flavonoid luteolin on neuronal differentiation in embryonic stem cells. Luteolin is a dietary flavonoid that has been researched due to its anti-cancer, antioxidant, and anti-inflammatory actions and is now being looked into for its supposed neuroprotective qualities. This study found that although luteolin does have some neuroprotective benefits it also has harmful side effects on neuronal development. Apigenin is a similar flavonoid that also has neuroprotective qualities but does not disrupt differentiation, emphasizing how slight differences in chemical structure can change the effects of a flavonoid.

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