Ameliorating Seizures in Dravet Syndrome: A Review of Newly Approved and Investigational Drugs, RNA and Gene-Based Therapies.
Dravet syndrome is a severe pediatric epilepsy with drug-resistant seizures. This review focuses on ameliorating seizures in Dravet syndrome using newly approved and investigational therapies. Cannabinoid and gene-based treatments show promise in…
Repeated Administration of Cannabidiol Decreases Splenic Lymphocyte Subset Numbers in Rats
This study investigates CBD immunomodulatory effects, revealing decreased splenic lymphocyte subset numbers in rats after repeated administration. The findings highlight cannabidiol's impact on immune cell populations. Understanding these effects is…
Therapeutic Potential of Cannabidiol Supplementation in Mitigating Lipid Precursors of Inflammation in Hepatic Steatosis Progression
This study investigated cannabidiol lipid inflammation effects on early-stage hepatic steatosis progression. Cannabidiol supplementation may modulate lipid precursors of inflammation in liver disease. These findings highlight cannabidiol's potential role…
Time Course of THC Tolerance Development and Loss in Mice
This study investigates the THC tolerance development timeline focusing on hypothermia and locomotor activity effects in mice. It reveals rapid tolerance onset and recovery patterns after cessation. Understanding THC tolerance development timeline aids…
Demographic Features, Health Status, and Behavioral Changes Associated with Cannabidiol Use in the Dog Aging Project
This study examines CBD use patterns companion dogs and their association with health status and behavioral changes. It provides valuable insights from the Dog Aging Project. Understanding these patterns helps inform clinical discussions about…
Cannabidiol Mitigates Pollution-Induced Inflammatory, Oxidative, and Barrier Damage in Ex Vivo Human Skin
CBD dermatology inflammation research reveals cannabidiol's ability to reduce pollution-induced skin damage. This study shows CBD mitigates inflammatory and oxidative stress in human skin. These findings highlight CBD's potential role in protecting skin…
Accidental Ingestion of Cannabis in Two Infants and a Preschool Child: Case Reports and Literature Review
Acute pediatric cannabis intoxication presents unique clinical challenges. This case series reports severe neurological symptoms in infants after accidental cannabis ingestion. Understanding these presentations is critical for timely diagnosis and care.
Recreational Cannabis Use During Human Pregnancy: Its Effects on the Placenta and Endocannabinoid System.
Cannabis use during pregnancy effects on the placenta and endocannabinoid system are increasingly studied due to rising usage rates. This research highlights potential disruptions in placental function and fetal development. Understanding these effects…
Evidence-Based Consensus on Pharmacological Management of Cannabis Dependence
The British Association for Psychopharmacology provides cannabis dependence pharmacological management guidelines based on current evidence. These guidelines highlight the limited pharmacological options and emphasize behavioral interventions. Clinicians…
Understanding the Toxicology of Orally Administered Δ⁹-THC
This article reviews the toxicology of orally administered delta-9-thc, highlighting dose-dependent effects observed in ruminants. Understanding oral delta-9-thc toxicity is crucial for safe clinical and veterinary applications. Careful dosing and…