Patient questions, answered by Dr. Benjamin Caplan, MD¹

We do not currently have human studies showing that cannabis nanoemulsions directly increase or decrease nitric oxide production. Cannabinoids themselves may influence nitric oxide signaling, with CBD showing evidence of supporting endothelial nitric oxide pathways while...

Clinical research indicates that cannabinoids do not "cure" PTSD or reliably lower total PTSD severity scores across the board, but they can offer targeted temporary relief for specific symptom clusters like traumatic nightmares, sleep disruption, and...

Cannabis compounds often produce what pharmacologists call a "biphasic effect," meaning low doses and higher doses can produce opposite reactions in the body. While a small amount of THC can calm the nervous system and relieve...

While early research suggests tetrahydrocannabivarin (THCV) may reduce appetite in some contexts, the evidence is not yet strong enough to call it a reliable or proven weight-loss tool. Because human studies are still limited and results...

The one trial that tested exactly this did not find a benefit. A CBD-rich extract taken before endodontic treatment did not reduce dental anxiety more than placebo, and postoperative pain was no different at 24 hours,...

For nausea that persists despite standard anti-sickness medicine, there is real evidence it helps. In a randomised trial, adding a THC:CBD capsule to the usual regimen raised the proportion of people who got through five days...

This is a very tricky question - with answers that keep changing with different papers and patient reports. For overall symptom burden, a recent randomized trial found no benefit beyond good palliative care - both groups...

There is, from a small but carefully designed trial. Twenty-two people with severe Tourette syndrome took both an oral THC/CBD oil and a placebo for six weeks each, and tic severity fell further on the active...

For now, less than the enthusiasm suggests. In a randomised trial of a high-CBD, low-THC extract, motor scores improved in both the treatment and placebo groups, and the difference between them was not statistically significant. Sleep,...