characterization of endocannabinoid and endogenous

Characterization of Endocannabinoid and Endogenous Opioid Levels in Adolescents With Cannabis Use Disorder

Cannabis Policy Wire
CED Clinical Relevance  #76Notable Clinical Interest  Emerging findings or policy developments worth monitoring closely.
🧪 Clinical Trial Watch  |  CED Clinic
Trial ID NCT05396638
Status Recruiting
Condition Cannabis Use
Intervention Contingency Management
Why This Matters

This trial addresses a critical gap in understanding how cannabis use disorder affects developing neurochemical systems in adolescents. Identifying biomarkers that predict relapse could transform how we approach treatment and monitoring in this vulnerable population.

Clinical Summary

This observational study is recruiting adolescents with cannabis use disorder to characterize endocannabinoid and endogenous opioid system changes through biomarker analysis. The trial uses contingency management as an intervention while measuring neurochemical markers to identify patterns that may distinguish youth likely to relapse from those who maintain sobriety. Participants undergo systematic assessment of endocannabinoid and opioid system function to establish baseline patterns and track changes over time.

Dr. Caplan’s Take

“If this research identifies reliable biomarkers for relapse risk, we could move toward personalized treatment approaches for adolescent cannabis use disorder. Having objective measures to guide intervention intensity and predict outcomes would represent a significant advance in adolescent addiction medicine.”

Clinical Perspective
🧠 Families should understand this is purely observational research that won’t directly treat cannabis use disorder but could inform future treatment strategies. The focus on biomarker discovery means results may not be immediately applicable to clinical care, though participation contributes to crucial knowledge about adolescent brain chemistry and addiction vulnerability.

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FAQ

This trial item was assembled from normalized source metadata and pipeline scoring.







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