Taurine attenuates lipid accumulation via the eCB-CB1 axis: evidence from adipose metabolomics in HFD-fed mice and 3D adipocyte spheroids.
Taurine lipid accumulation modulation via the eCB-CB1 axis offers new insights into obesity management. This study highlights taurine's role in adipose tissue metabolism. Findings suggest potential pathways for metabolic disorder interventions.
Cannabinoids and cognition in Parkinson’s disease: Insights from animal models and emerging clinical evidence.
Cannabinoids and cognition in Parkinson's disease are increasingly studied due to the endocannabinoid system's role in neural circuits affected by PD. Animal models show promising neuroprotective and cognition-preserving effects of cannabinoids. However,…
Enhancing Endocannabinoid System for Residual Disease in MS
This clinical study endocannabinoid system approach addresses residual disease in relapse-free multiple sclerosis patients. High-efficacy therapies reduce relapses but symptoms persist. Enhancing the endocannabinoid system offers new treatment insights.
Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.
The LPI GPR55 receptor axis plays a crucial role in metabolic dysfunction-associated fatty liver disease (MAFLD). This pathway contributes to liver fat accumulation, inflammation, and fibrosis. Understanding this axis offers novel insights into potential…
Cannabinoids in Combination with Conventional Breast Cancer Therapies: Mechanistic Insights and the Gap to Clinical Translation.
This review highlights cannabinoid anti-tumor effects breast cancer research and its potential to enhance conventional therapies. It emphasizes the gap between preclinical findings and clinical translation. Understanding these effects is crucial for…
Pharmacokinetic and Pharmacodynamic Properties of Cannabigerol in Male Mice
This study investigates the pharmacokinetic properties of cannabigerol in male mice, highlighting its brain penetration and metabolite accumulation. Findings reveal unexpected anxiogenic effects at peak brain concentrations. Understanding these…
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control
CBD motor function treatment-resistant epilepsy research highlights its potential to improve seizure control while preserving motor abilities. This dual impact addresses a critical gap in epilepsy management. Patients with treatment-resistant epilepsy…
Personalized Resilience: Variability in Brain-Immune Stress Responses
Brain-immune responses to stress vary significantly among individuals, influencing anxiety disorder development. This variability affects HPA axis regulation and immune function. Understanding these responses is key to personalized resilience strategies.
Spontaneous Pneumomediastinum and Cannabinoid Hyperemesis Syndrome: A Case Report and Literature Review
This case report highlights spontaneous pneumomediastinum as a rare complication of cannabinoid hyperemesis syndrome. An 18-year-old chronic cannabis user developed spontaneous pneumomediastinum following severe vomiting. Understanding this complication…
Cannabis Hyperemesis Syndrome: A Psychiatric Approach
Cannabis hyperemesis syndrome psychiatric risk is a critical consideration in patients with chronic cannabis use presenting with cyclical vomiting. This syndrome often poses diagnostic challenges in psychiatric settings due to overlapping symptoms. Early…