Self-reported Use of Cannabidiol as Substitute or Adjunct for Medications
This study examines cbd drug interactions patient safety by assessing how US adults use cannabidiol as a substitute or adjunct for approved medications. It highlights the importance of clinician awareness during medication reconciliation. Understanding…
A simple, sensitive and rapid bioanalytical method for quantifying cannabidiol (CBD), 7-OH-CBD and 7-COOH-CBD in human plasma.
This bioanalytical method cannabidiol plasma quantification provides reliable measurement of CBD and its metabolites in human plasma. Accurate plasma quantification is essential for pharmacokinetic studies and therapeutic monitoring. The method is…
Progressive Endocannabinoid System Dysregulation in Autosomal Dominant Polycystic Kidney Disease
This study highlights endocannabinoid system dysfunction ADPKD as a progressive factor in autosomal dominant polycystic kidney disease. Researchers found altered endocannabinoid markers correlating with disease severity. Understanding this dysfunction…
Biobio Sentinel: Two years of illicit drug surveillance in South-Central Chile.
Wastewater-based epidemiology provides objective data on cannabis consumption trends in South-Central Chile. This method offers valuable insights into community-level drug use patterns. The study highlights significant shifts in illicit drug surveillance…
Prenatal THC Exposure and Binge-Like Alcohol Drinking in Early Adolescence
Prenatal THC exposure adolescent alcohol drinking risk is linked to altered brain reward pathways. This study highlights sex-specific drinking vulnerabilities during early adolescence. The endocannabinoid-dopamine nexus in the nucleus accumbens plays a…
Cannabidiol and Escitalopram: Faster Behavioral Effects in Stress Models
CBD SSRI adjunctive therapy shows promise in reducing the latency of antidepressant effects. This preclinical study highlights faster behavioral improvements with combined treatment. The findings suggest potential clinical relevance for mood disorder…
Recent Trends in Cannabis Use in Adults Ages 60 Years and Older.
Cannabis use in adults 60 and older is rapidly increasing, with many using it for medical reasons such as pain and insomnia. This review highlights important health considerations for this demographic. Understanding cannabis use in adults 60 and older is…
Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics
Hemp-derived extracellular vesicles represent a promising breakthrough in cannabis medicine, offering a natural delivery system for cannabinoids and other compounds. These vesicles provide advantages over mammalian-derived counterparts, including better…
Polycyclic Aromatic Hydrocarbons and Cannabinoids in Secondhand Cannabis Smoke
Secondhand cannabis smoke health risks include exposure to cannabinoids and polycyclic aromatic hydrocarbons (PAHs). This study measures these compounds in real-world environments. Understanding these risks is vital for clinicians and patients.
Cannabigerol Induces ER Stress-Mediated Apoptosis and Ferroptosis in Pancreatic Cancer
Cannabigerol pancreatic cancer cells research reveals dual mechanisms of cell death: apoptosis and ferroptosis. This study highlights the role of endoplasmic reticulum stress via the IRE1α-XBP1 axis. These findings provide promising preclinical insights…