Opioid Use Disorder Among Cervical Fusion Inpatients: Trends, Complications, and Resource Use in a Retrospective National Inpatient Sample Analysis, 2016-2022.
A large retrospective study reveals that opioid use disorder affects 3.4% of cervical fusion surgery patients, with these individuals experiencing significantly longer hospital stays and higher complication rates. This population-level data provides…
The cannabidiol (CBD): Tetrahydrocanabinol (THC) concentration ratio is critical for neuroprotection and recovery following traumatic brain injury.
Preclinical research demonstrates that specific CBD THC ratio neuroprotection mechanisms outperform CBD isolate in traumatic brain injury models. This study supports the entourage effect hypothesis while highlighting the need for human clinical trials to…
12-Month Patient-Reported Outcomes Among Urine Toxicology-Identified Substance Users After Elective Spine Surgery: A Prospective Longitudinal Cohort Study.
While prior studies have examined the role of opioids, alcohol, and marijuana use on early postoperative outcomes after elective spine surgery, longitudinal ...
Fear of recurrence, secondary cancers, and health problems in long-term survivors of childhood cancer: Findings from a Canadian cohort.
Survivors of childhood cancer are at lifelong risk for health problems, secondary cancers, and recurrence. However, little is known about their fears related...
Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens.
Preclinical research reveals that prenatal THC exposure disrupts developing brain reward circuits and increases adolescent alcohol drinking vulnerability through sex-specific changes in endocannabinoid-dopamine signaling. These findings support clinical…
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges.
New preclinical research reveals CBD's potential to address multiple pathways in diabetic heart disease, including inflammation and oxidative stress. However, the cbd diabetic heart disease preclinical evidence requires human clinical trials before any…
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Research validates meconium cannabis testing pregnancy detection as more sensitive than maternal urine for identifying third trimester cannabis exposure. This forensic methodology study provides clinicians with improved detection capabilities for…
Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1.
Recent research demonstrates that cannabidiphorol (CBDP) acts as a negative allosteric modulator at CB1 receptors through a novel dual-site mechanism. This finding suggests CBDP could potentially provide therapeutic cannabinoid system modulation without…
Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project.
The Dog Aging Project's survey of over 20,000 dog owners provides the first large-scale analysis of CBD use patterns in companion dogs study, revealing how owner demographics and perceived health needs drive cannabidiol administration decisions. While…
Evidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology.
New expert consensus guidelines include evidence-based recommendations for cannabis use disorder treatment alongside other substance dependencies. The British Association for Psychopharmacology guidelines provide clinicians with systematic approaches to…
