Endocannabinoid System Research and Medical Cannabis Dosing Guide
This medical cannabis dosing guide highlights key findings from endocannabinoid system research. It provides clinicians with evidence-based recommendations for cannabis dosing. Understanding this guide supports safer and more effective patient care.
The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.
This clinical review examines how oral dysbiosis cardiovascular disease mechanisms create systemic inflammation and vascular damage. Evidence shows periodontal therapy can reduce cardiovascular risk markers, establishing oral health as a modifiable risk…
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
A real-time smartphone-based study of 258 MS patients revealed that higher pain levels drive increased cannabis use and decreased alcohol consumption. This research using ecological momentary assessment provides clinical evidence that MS patients make…
Attitudes, beliefs and willingness to prescribe medical cannabis among public medical practitioners in Malaysia.
A nationwide survey of Malaysian physicians reveals measured acceptance of medical cannabis, with 65% supporting availability for certain conditions. The strongest support emerged for pain management applications, where 87% of doctors endorsed medical…
Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties.
Laboratory research has identified prenylated apigenin derivatives from Cannabis sativa with anti-inflammatory properties, representing novel non-psychotropic compounds beyond traditional cannabinoids. While these prenylated apigenin cannabis…
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
A preclinical study found that CBD accelerates antidepressant effects and enhances SSRI response at lower doses in stressed mice. While promising, these animal findings require clinical validation before informing human treatment protocols.
The effect of daily aerobic cycling exercise on cannabis withdrawal: An inpatient randomised controlled trial.
A randomized controlled trial of 46 adults found that daily aerobic cycling exercise significantly reduced cannabis withdrawal symptom severity during the critical first week of abstinence. This represents the first controlled evidence that aerobic…
Acute and long-term psychiatric consequences of synthetic cannabinoids and related novel psychoactive substances: A systematic review.
A comprehensive systematic review demonstrates that synthetic cannabinoid psychiatric complications long term effects can persist for at least six months beyond use. This finding distinguishes synthetic cannabinoids from traditional cannabis and informs…
Unveiling the Complex Interplay: Sudden Emergence of First-Rank Schneiderian Symptoms Following TMS in a Patient With Severe Depression and Complex Trauma.
A case report documents synthetic cannabinoid induced psychosis developing after TMS treatment in a depressed patient. This highlights the need for comprehensive substance screening before neuromodulation therapies. Synthetic cannabinoids pose…
A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.
A randomized controlled trial demonstrates that a smartphone-based digital intervention for substance use disorders achieved greater reductions in substance use occasions compared to psychoeducational content alone. This research supports the potential…
