Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives.
This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis. This s...
Cannabigerol induces endoplasmic reticulum stress-mediated apoptosis and ferroptosis via the IRE1α-XBP1 axis in human pancreatic cancer cells.
Cannabigerol (CBG), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has attracted increasing attention owing to its antibiotic, anti-inflam...
Medicinal Cannabis Prescription Before an Inpatient Psychiatric Admission: A Retrospective Observational Audit.
Prescribing of medicinal cannabis has expanded in Australia; however, evidence for benefit in psychiatric populations is limited. The goal of this study was ...
Effects and mechanisms of cannabidiol in attenuating orofacial inflammatory pain and ameliorating pain-related affective deficits.
A new preclinical study found that cannabidiol orofacial inflammatory pain study showed promising results in reducing both sensory and emotional aspects of facial pain in laboratory mice. While encouraging for future research directions, these animal…
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Researchers found that increasing FABP5 protein expression in mouse brain amygdala reduces stress-induced cocaine-seeking behavior. This endocannabinoid system cocaine addiction treatment research provides insights into potential therapeutic targets,…
Contentious legality in decentralized governance: The rise and decline of cannabis social clubs in Spain.
A comprehensive policy analysis reveals how Spanish cannabis social clubs legal framework exploited legal ambiguities to create community-based alternatives to illicit markets. The study demonstrates how grassroots activism and strategic legal…
Neuropathic Pain Severity Is Associated With Opioid Use in Adults With Traumatic Spinal Cord Injury: A Spinal Cord Injury Model System Study.
A new study of 283 spinal cord injury patients reveals that neuropathic pain severity predicts opioid use, while employment status reduces opioid dependence risk by 33%. The research highlights complex medication patterns including cannabis combinations…
Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031).
A phase 2 open-label trial evaluated transdermal CBD for 22q11.2 deletion syndrome in children, demonstrating tolerability with preliminary behavioral improvements. While promising for this rare genetic condition, controlled trials are needed to…
The toxicology of orally administered Δ
A toxicology study in Merino ewes demonstrates that oral THC administration produces measurable adverse effects including ataxia and reduced feed intake. These findings highlight important THC toxicity in livestock hemp feed safety considerations for the…
Preventing alcohol and cannabis-impaired driving among adolescents: Effects of a web-intervention in a driver education program.
A randomized trial found that adding a 30-minute web intervention to driver education significantly reduced adolescent intentions for cannabis impaired driving prevention. The intervention worked by changing perceived peer approval of substance use…
