Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.
China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on sum...
Molecular Basis Underlying Changes of Brain Entropy and Couplings in Late-life Depression.
Late-life depression (LLD) with high prevalence accelerates cognitive impairment and becomes a risk factor for dementia, yet the pathogenesis of LLD is still...
Independent Factors Associated With Opioid Refills After Inpatient Otolaryngology-Head and Neck Surgery.
A large cohort study of opioid refills after head and neck surgery reveals that higher discharge opioid doses predict increased refill requests within 90 days. This finding supports more conservative initial opioid prescribing strategies to reduce the…
Beyond Epilepsy Control: Repurposing Antiepileptic Drugs in Central Nervous System Tumor Therapy.
A comprehensive review explores cannabidiol brain tumor antiepileptic mechanisms and suggests potential antitumor activity in CNS cancers. The analysis identifies multiple pathways through which CBD and other antiepileptic drugs might combat brain tumors…
Opioid Use Disorder Among Cervical Fusion Inpatients: Trends, Complications, and Resource Use in a Retrospective National Inpatient Sample Analysis, 2016-2022.
A large retrospective study reveals that opioid use disorder affects 3.4% of cervical fusion surgery patients, with these individuals experiencing significantly longer hospital stays and higher complication rates. This population-level data provides…
The cannabidiol (CBD): Tetrahydrocanabinol (THC) concentration ratio is critical for neuroprotection and recovery following traumatic brain injury.
Preclinical research demonstrates that specific CBD THC ratio neuroprotection mechanisms outperform CBD isolate in traumatic brain injury models. This study supports the entourage effect hypothesis while highlighting the need for human clinical trials to…
12-Month Patient-Reported Outcomes Among Urine Toxicology-Identified Substance Users After Elective Spine Surgery: A Prospective Longitudinal Cohort Study.
While prior studies have examined the role of opioids, alcohol, and marijuana use on early postoperative outcomes after elective spine surgery, longitudinal ...
Fear of recurrence, secondary cancers, and health problems in long-term survivors of childhood cancer: Findings from a Canadian cohort.
Survivors of childhood cancer are at lifelong risk for health problems, secondary cancers, and recurrence. However, little is known about their fears related...
Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens.
Preclinical research reveals that prenatal THC exposure disrupts developing brain reward circuits and increases adolescent alcohol drinking vulnerability through sex-specific changes in endocannabinoid-dopamine signaling. These findings support clinical…
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges.
New preclinical research reveals CBD's potential to address multiple pathways in diabetic heart disease, including inflammation and oxidative stress. However, the cbd diabetic heart disease preclinical evidence requires human clinical trials before any…
