Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids.
Neurocutaneous dysesthesia (ND) is characterized by abnormal skin sensations such as pruritus or burning without an underlying skin condition. It is caused b...
The effect of cannabis use on the time course of positive and negative affect in the daily life of youth.
Recent research examining cannabis effects on youth daily mood patterns found that cannabis use reduced negative affect but did not significantly enhance positive emotions. This study provides important insights into how young people experience cannabis…
Cannabinoid Clinical Trials: Mental Health Evidence
Clinical Takeaway Clinical Takeaway: Current randomized controlled trial evidence does not demonstrate established efficacy or safety of cannabinoids as primary treatment for mental disorders or substance use disorders. Existing research gaps mean…
Cannabinoid Clinical Trials: Mental Health Evidence Review
✦ New CED Clinical Relevance #78 Strong Clinical Relevance High-quality evidence with meaningful patient or clinical significance. Mental HealthResearchSafetyNeurologyCBD Why This Matters Clinicians need this evidence synthesis to make informed…
Cannabis Retailer Advice on Blunt, Tobacco, and Cannabis Use During Pregnancy.
A new study examining cannabis budtender advice during pregnancy reveals concerning gaps between retail recommendations and medical evidence. Healthcare providers must address these conflicting information sources to ensure pregnant patients receive…
Synthetic cannabinoids in Mayotte over a year in time and space: an example of high-frequency evolution of market.
Researchers used synthetic cannabinoid wastewater monitoring surveillance to track market evolution in Mayotte over one year. The environmental monitoring approach revealed rapid changes in synthetic cannabinoid composition and geographic distribution,…
Mobile app-based study of driving behaviors under the influence of cannabis.
A small study of 9 participants found correlations between cannabis use and altered driving behaviors using cannabis driving impairment smartphone detection technology. The research demonstrates feasibility of real-world monitoring but requires larger…
New and emerging treatments for anxiety disorders.
New clinical review identifies ashwagandha for anxiety treatment among promising natural supplements and novel therapies. Research explores alternatives for treatment-resistant anxiety including L-theanine, neurostimulation, and innovative psychotherapy…
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis.
Researchers developed HKC54, a selective TRPV2 antagonist that inhibits cancer cell migration in laboratory studies. This TRPV2 antagonist cancer cell migration research represents early-stage drug development that could eventually lead to new…
The quality and scope of health information on online drug platforms: a topic modelling and expert evaluation study of a Polish-language forum.
Determining health information quality on online drug platforms is crucial for revealing and shaping substance use practices. The study aims to assess the sc...
