Therapeutic potential of acidic cannabinoids: an update.
A comprehensive review of acidic cannabinoids therapeutic potential reveals that THCA, CBDA, and related compounds offer unique neuroprotective and anti-inflammatory benefits distinct from THC and CBD. This systematic analysis challenges the traditional…
Exploring the neuroprotective effects of phytocannabinoids on oxygen-glucose deprived neurons in an in vitro model of stroke.
Recent laboratory research on cannabinoids for stroke neuroprotection showed modest benefits from seven phytocannabinoids in protecting brain cells. While promising, these early findings require extensive additional research before clinical applications.
NfL and GFAP quantification and associations with mental health in recreational cannabis users-Results from the Swiss study on recreational cannabis access via pharmacies.
A Swiss study measuring cannabis brain damage biomarkers study results in 331 regular users found no evidence of nerve damage and unexpectedly lower levels of brain injury markers. These objective biomarker findings challenge assumptions about cannabis…
Comparison of Perspectives on Cannabis Use Between Emergency Department Patients Who Are Users and Non-users.
A prospective survey study found emergency department patients who use cannabis demonstrate superior knowledge of its effects compared to non-users. This cannabis knowledge emergency department patients research suggests clinicians should tailor…
Medical Cannabis Use in Autism: Insights from an Israeli HMO on Patient Characteristics and Alignment with National Guidelines.
A large Israeli healthcare study examining medical cannabis prescribing patterns autism children found only 1.2% of autistic individuals received prescriptions, but concerning pediatric use patterns suggest need for stricter clinical oversight and…
Randomised Controlled Trial Evidence on Medicinal Cannabis for Treatment of Mental Health and Substance Use Disorders: A Scoping Review.
A comprehensive scoping review of randomized controlled trials reveals limited high-quality medicinal cannabis mental health evidence for treating psychiatric and substance use disorders. The systematic review highlights significant gaps in rigorous…
Health-related quality of life in patients receiving medicinal cannabis: systematic review and meta-analysis of primary research findings 2015-2025.
A comprehensive systematic review and meta-analysis examining medicinal cannabis quality of life outcomes found consistent improvements across chronic conditions. The research analyzed validated HRQL measures from 2015-2025, showing benefits in short,…
What a 2026 Lancet Psychiatry Review Actually Shows, and What It Doesn’t
This cannabinoids mental health meta-analysis reviews 54 randomized trials across psychiatric and substance use conditions. It identifies modest benefits in insomnia, Tourette syndrome, ASD traits, and cannabis withdrawal, but with low certainty. For…
Radical Revelations: The Interplay of Nitrosative Stress, the Endocannabinoid System, and Treatment of Age-Related Disorders.
New endocannabinoid system neurodegeneration research reveals complex interactions between cannabis compounds and brain inflammatory pathways. This review examines how ECS modulation may influence nitrosative stress in neurodegenerative diseases.…
Distribution and subacute modulation of endocannabinoid metabolizing enzymes in the trigeminal complex and midbrain in a pre-clinical model of post-traumatic headache.
Pre-clinical research identifies endocannabinoid system dysfunction as a potential mechanism underlying post-traumatic headache. The study reveals increased enzymes that break down protective endocannabinoids in pain circuits following mild traumatic…