Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.
A methodology study examining cannabis research selection bias found systematic differences between participants who accept versus decline assigned cannabis conditions. This quasi-randomization research provides crucial insights for interpreting legal…
Cannabidiol as a Prophylactic Agent Against Glioblastoma Growth: A Preclinical Investigation.
A new preclinical study demonstrates that CBD glioblastoma prevention may be possible through extended pretreatment in mice. While promising, this early research requires extensive human studies before any clinical applications. Dr. Caplan explains what…
Clinical Decision-Making in Laparoscopic Common Bile Duct Exploration: Choosing Between Primary Closure and T-Tube Drainage.
This narrative review demonstrates that laparoscopic bile duct exploration primary closure provides superior outcomes compared to T-tube drainage when complete stone clearance is achieved. Evidence shows shorter operative times, reduced hospital stays,…
Muscular Dystrophy Muscle Preservation: A Comparative Systematic Review of Exercise and Cannabidiol (CBD) Interventions.
A new systematic review comparing exercise therapy muscular dystrophy muscle preservation strategies finds that exercise interventions demonstrate consistent functional benefits while cannabidiol evidence remains limited to preclinical studies. This…
Plasma cannabinoid pharmacokinetics following the inhalation of vaporised cannabis with and without cannabidiol.
A randomized controlled trial found that CBD effects on THC plasma concentrations were minimal when cannabis was vaporized, challenging assumptions about CBD reducing THC bioavailability. The study showed similar cannabinoid pharmacokinetics between…
Regular cannabinoid use and inflammatory biomarkers: Systematic review and hierarchical meta-analysis.
A comprehensive systematic review of cannabis inflammatory biomarkers found associations with anti-inflammatory markers in observational studies. However, the clinical significance of these laboratory changes remains uncertain, and the predominance of…
Cannabis & Dental Care
Clinical Relevance #62 Emerging but Limited Evidence Mechanistic promise exists, but clinical translation remains early and uncertain. Clinical Insight Cannabis in dentistry is biologically plausible but clinically immature. The key risk is…
Baseline characteristics and feasibility of clinical outcome measures in CDKL5 deficiency disorder: The CANDID observational study.
A large observational study successfully validates clinical outcome measures in CDKL5 deficiency disorder, revealing severe early-onset epilepsy with median seizure onset at 1.5 months. This research establishes crucial infrastructure for evaluating…
Discrepancies between subjective and objective cognition in persons with multiple sclerosis: Exploring the role of cannabis use.
Research examining cannabis cognitive effects in multiple sclerosis patients found that cannabis users report greater perceived cognitive deficits than non-users. This cross-sectional study of 847 MS patients provides important insights into the…
Unveiling Neurological Benefits: A Review of Hemp Leaf, Flower, Seed Oil Extract, and Their Phytochemical Properties in Neurological Disorders.
A new review examines hemp extract neurological disorders research, analyzing potential therapeutic applications for epilepsy, Alzheimer's, and Parkinson's disease. This clinical analysis explores what the evidence shows and doesn't show about…