Pilot study on cannabis-induced alterations in platelet function: implications for transfusion medicine.
A pilot study reveals cannabis extracts can alter platelet function in laboratory settings, raising questions about cannabis effects on platelet function and transfusion safety. While preliminary, this research highlights the need for further…
Associations of Prenatal Cannabis Exposure and Neonatal Brain Development in the HBCD Cohort.
A major cohort study demonstrates that prenatal cannabis exposure brain development effects are detectable through neuroimaging in newborns. This research provides objective evidence supporting current recommendations to avoid cannabis during pregnancy…
Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy.
A new preclinical study demonstrates that prenatal cannabis smoke exposure crosses the placental barrier and disrupts fetal development in mice. This research provides biological evidence supporting clinical recommendations against cannabis use during…
Associations Between Cannabis Use and Inflammatory Biomarkers Among People with HIV.
A new cohort study found associations between current cannabis use and lower inflammatory biomarkers in people with HIV on antiretroviral therapy. While the cannabis inflammatory biomarkers HIV patients research is intriguing, the cross-sectional design…
A single dose of cannabidiol increases ad libitum energy intake in healthy adults but does not affect postprandial glucose or lipid metabolism.
A randomized controlled trial found that CBD appetite effects included a significant 193-calorie increase in food intake among healthy adults. This CBD appetite effects study challenges assumptions about cannabidiol's impact on eating behavior and…
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
A narrative review examines how CBD hyperarousal insomnia mechanistic pathways may involve endocannabinoid, inflammatory, and autonomic system modulation. While mechanistically plausible, this theoretical framework requires clinical validation before…
Cannabidiol-Loaded Mucoadhesive PLGA Nanosphere-Chitosan Hydrogel Patch for Oral Therapeutic Applications.
Researchers developed a CBD hydrogel patch with sustained release properties that achieved over 90% drug release within 96 hours in laboratory testing. While the CBD hydrogel patch sustained release technology shows promise for addressing bioavailability…
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control.
A comprehensive review demonstrates CBD's potential for seizure control while maintaining motor function in epilepsy models. This motor-sparing profile of CBD distinguishes it from traditional antiepileptics that often impair movement and coordination.…
Synergistic Neuroimmune Modulation by Cannabidiol and Probiotics for Therapeutic Advancement in CNS Disorders: A Systematic Review.
New systematic review identifies mechanistic pathways for CBD probiotics gut brain axis synergy in neurological disorders. While biologically plausible, combination therapy effectiveness requires controlled clinical trials before therapeutic…
Quasi-randomization to Cannabinoid Condition in Studies of US Legal Market Cannabis: Characteristics of Accepters Versus Decliners of Condition Assignment.
A methodology study examining cannabis research selection bias found systematic differences between participants who accept versus decline assigned cannabis conditions. This quasi-randomization research provides crucial insights for interpreting legal…