Defining Cannabis Use Disorder in Administrative Health Data: A Systematic Review of Case Definitions and Validation Approaches.
A systematic review of 56 studies reveals concerning inconsistencies in how cannabis use disorder administrative data validation occurs across health systems. Most studies used ICD diagnostic codes without proper validation, undermining the reliability…
Cannabis and Mental Health: A Review.
A comprehensive JAMA review reveals the stark gap between widespread cannabis use for mental health conditions and actual clinical evidence. While patients commonly self-medicate with cannabis for psychiatric symptoms, this systematic analysis found…
Prevalence and Correlates of Symptoms of Cannabinoid Hyperemesis Syndrome in the United States.
A groundbreaking national survey reveals cannabinoid hyperemesis syndrome prevalence affects nearly 1 in 5 daily cannabis users. This first population-level study provides critical data for clinicians treating cannabis-related health issues. The findings…
Canadian real-world evidence: observational 24-week outcomes for health care practitioner authorized cannabis.
A large Canadian observational study demonstrates medical cannabis real world effectiveness across chronic pain, anxiety, and sleep disorders over 24 weeks. This real-world evidence provides clinicians with practical outcome expectations for sustained…
Cannabidiol blood metabolite levels after cannabidiol treatment are associated with broadband EEG changes and improvements in visuomotor and non-verbal cognitive abilities in boys with autism requiring higher levels of support.
A rigorous clinical trial found that CBD autism spectrum disorder clinical trial results showed measurable brain activity changes in children with high-support autism. While promising for understanding CBD's neurological effects, the study did not…
Federal Marijuana Rescheduling to Schedule III: What It Means for Your Practice and Patients
Schedule III cannabis clinical practice has formally arrived. On April 23, 2026, the Justice Department placed FDA-approved marijuana products and state-regulated medical cannabis in Schedule III, with an expedited hearing June 29 to consider full…
Metformin reverses oxandrolone-induced anxiety-like behavior and amygdalar neurochemical dysregulation in male rats.
Oxandrolone, a synthetic anabolic androgenic steroid, is widely used for its muscle-building effects but has been associated with anxiety and mood disturbanc...
Parental sociodemographic profiles in relation to mental health, cannabis use motives, and cannabis use behaviors among a sample of US young adult parents.
Although past-month cannabis use has increased among US parents, little work has identified factors associated with parental use. We analyzed 2023 survey dat...
Sexualized alcohol and drug use among men who have sex with men and the PrEP retention in Thailand.
Research among Thai MSM shows that sexualized substance use patterns create distinct barriers to PrEP retention, suggesting clinicians should screen for these behaviors and consider enhanced support strategies. The findings highlight how combining…
Use of Complementary Health Approaches and Research Interests Among Older Adults in the COSMOS Trial.
A comprehensive survey of over 16,000 older adults revealed that complementary health approaches in older adults are mainstream, with nearly 60% reporting recent use. This prevalence data has significant implications for how clinicians should approach…