The effect of daily aerobic cycling exercise on cannabis withdrawal: An inpatient randomised controlled trial.
A randomized controlled trial of 46 adults found that daily aerobic cycling exercise significantly reduced cannabis withdrawal symptom severity during the critical first week of abstinence. This represents the first controlled evidence that aerobic…
Acute and long-term psychiatric consequences of synthetic cannabinoids and related novel psychoactive substances: A systematic review.
A comprehensive systematic review demonstrates that synthetic cannabinoid psychiatric complications long term effects can persist for at least six months beyond use. This finding distinguishes synthetic cannabinoids from traditional cannabis and informs…
Unveiling the Complex Interplay: Sudden Emergence of First-Rank Schneiderian Symptoms Following TMS in a Patient With Severe Depression and Complex Trauma.
A case report documents synthetic cannabinoid induced psychosis developing after TMS treatment in a depressed patient. This highlights the need for comprehensive substance screening before neuromodulation therapies. Synthetic cannabinoids pose…
A relational agent for treating substance use in adults: A randomized controlled trial with a psychoeducational comparator.
A randomized controlled trial demonstrates that a smartphone-based digital intervention for substance use disorders achieved greater reductions in substance use occasions compared to psychoeducational content alone. This research supports the potential…
Modulating the endocannabinoid system in alcohol use disorder: A translational systematic review and meta-analysis of preclinical and human studies.
A comprehensive systematic review examining CBD alcohol use disorder treatment potential found that CBD consistently reduced alcohol consumption in preclinical studies. However, human clinical data remains insufficient to support treatment…
Associations of cannabis use, other substances, and lifestyle choices on anxiety in medical cannabis patients across 45 days.
Previous research has shown medical cannabis (MC) to help reduce anxiety for some individuals, although most studies show trends using cross-sectional design...
From Analgesia to Synaptic Remodeling: A Systematic Review of Acetaminophen’s Neuromodulatory Effects.
Neuro-related disorders will be rising globally. Current treatments have numerous limitations that can impair patients' quality of life. One of the key thera...
A sesquiterpene-rich essential oil from Cannabis sativa L. attenuates symptoms and neuroinflammation in experimental autoimmune encephalomyelitis model through a CB2-mediated signalling.
Researchers found that cannabis essential oil neuroinflammation reduction occurred through CB2 receptor activation in an experimental multiple sclerosis model. The sesquiterpene-rich formulation improved pain, motor function, and emotional symptoms…
Relationship of Ethanol, Cannabinoids, Benzodiazepines, and Opioids to Serious Injuries from Falls in Adults Aged 55 and Older.
A trauma center study of 274 adults over 55 found that cannabis use and falls in elderly adults was not associated with increased injury severity. This objective toxicological data challenges assumptions about cannabis-related fall risk and provides…
Highly purified cannabidiol (CBD) in CDKL5 deficiency disorder (CDD): Open-label prospective study.
A new open-label study examining CBD for CDKL5 deficiency disorder treatment found 89% of patients continued therapy for 12 months. While retention rates suggest tolerability, efficacy data remains limited in this rare developmental epilepsy condition.