Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics.
While mammalian-derived extracellular vesicles (EVs) face significant challenges in clinical translation due to scalability, cost, and safety, plant-derived ...
Polycyclic aromatic hydrocarbons and cannabinoids in secondhand cannabis smoke.
The legalization of cannabis is exposing more people to secondhand smoke (SHS) generated during cannabis use. Given the serious health effects caused by toba...
Cannabis stigma and symptom management considerations in cancer survivors: a mixed-methods exploration of patient perspectives.
This study aims to assess for indications of stigma and attitudes toward cannabis among cancer survivors (CS) who use or consider the use of cannabis. This s...
Cannabigerol induces endoplasmic reticulum stress-mediated apoptosis and ferroptosis via the IRE1α-XBP1 axis in human pancreatic cancer cells.
Cannabigerol (CBG), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has attracted increasing attention owing to its antibiotic, anti-inflam...
Medicinal Cannabis Prescription Before an Inpatient Psychiatric Admission: A Retrospective Observational Audit.
Prescribing of medicinal cannabis has expanded in Australia; however, evidence for benefit in psychiatric populations is limited. The goal of this study was ...
Effects and mechanisms of cannabidiol in attenuating orofacial inflammatory pain and ameliorating pain-related affective deficits.
A new preclinical study found that cannabidiol orofacial inflammatory pain study showed promising results in reducing both sensory and emotional aspects of facial pain in laboratory mice. While encouraging for future research directions, these animal…
Tuberculous Peripancreatic Lymphadenitis Presenting as Obstructive Jaundice Due to Extrinsic Common Bile Duct Compression: A Case Report.
A case report demonstrates how tuberculous peripancreatic lymphadenitis bile duct obstruction can present as obstructive jaundice in patients from TB-endemic regions. The case highlights the importance of considering extrapulmonary tuberculosis in the…
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Researchers found that increasing FABP5 protein expression in mouse brain amygdala reduces stress-induced cocaine-seeking behavior. This endocannabinoid system cocaine addiction treatment research provides insights into potential therapeutic targets,…
Contentious legality in decentralized governance: The rise and decline of cannabis social clubs in Spain.
A comprehensive policy analysis reveals how Spanish cannabis social clubs legal framework exploited legal ambiguities to create community-based alternatives to illicit markets. The study demonstrates how grassroots activism and strategic legal…
Neuropathic Pain Severity Is Associated With Opioid Use in Adults With Traumatic Spinal Cord Injury: A Spinal Cord Injury Model System Study.
A new study of 283 spinal cord injury patients reveals that neuropathic pain severity predicts opioid use, while employment status reduces opioid dependence risk by 33%. The research highlights complex medication patterns including cannabis combinations…