Phase 2, open-label INSPIRE trial to assess the tolerability and effectiveness of transdermal cannabidiol gel in children and adolescents with 22q11.2 deletion syndrome (ZYN2-CL-031).
A phase 2 open-label trial evaluated transdermal CBD for 22q11.2 deletion syndrome in children, demonstrating tolerability with preliminary behavioral improvements. While promising for this rare genetic condition, controlled trials are needed to…
Complete radiologic and clinical reversal of lumbar spinal epidural lipomatosis via GLP-1 agonist.
This landmark case demonstrates complete radiologic reversal of severe spinal epidural lipomatosis through GLP-1 agonist-induced weight loss combined with medical cannabis pain management. The patient avoided surgical decompression while achieving…
The toxicology of orally administered Δ
A toxicology study in Merino ewes demonstrates that oral THC administration produces measurable adverse effects including ataxia and reduced feed intake. These findings highlight important THC toxicity in livestock hemp feed safety considerations for the…
Preventing alcohol and cannabis-impaired driving among adolescents: Effects of a web-intervention in a driver education program.
A randomized trial found that adding a 30-minute web intervention to driver education significantly reduced adolescent intentions for cannabis impaired driving prevention. The intervention worked by changing perceived peer approval of substance use…
Endocannabinoid System Research and Medical Cannabis Dosing Guide
This medical cannabis dosing guide highlights key findings from endocannabinoid system research. It provides clinicians with evidence-based recommendations for cannabis dosing. Understanding this guide supports safer and more effective patient care.
The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.
This clinical review examines how oral dysbiosis cardiovascular disease mechanisms create systemic inflammation and vascular damage. Evidence shows periodontal therapy can reduce cardiovascular risk markers, establishing oral health as a modifiable risk…
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
A real-time smartphone-based study of 258 MS patients revealed that higher pain levels drive increased cannabis use and decreased alcohol consumption. This research using ecological momentary assessment provides clinical evidence that MS patients make…
Attitudes, beliefs and willingness to prescribe medical cannabis among public medical practitioners in Malaysia.
A nationwide survey of Malaysian physicians reveals measured acceptance of medical cannabis, with 65% supporting availability for certain conditions. The strongest support emerged for pain management applications, where 87% of doctors endorsed medical…
Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties.
Laboratory research has identified prenylated apigenin derivatives from Cannabis sativa with anti-inflammatory properties, representing novel non-psychotropic compounds beyond traditional cannabinoids. While these prenylated apigenin cannabis…
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
A preclinical study found that CBD accelerates antidepressant effects and enhances SSRI response at lower doses in stressed mice. While promising, these animal findings require clinical validation before informing human treatment protocols.