When Adults With ADHD Should Consider Stimulant Deprescribing
medical cannabis research: A psychopharmacology task force used literature review and Delphi consensus to clarify when adult ADHD stimulant deprescribing deserves serious consideration, including misuse, diagnostic uncertainty, absent benefit, and…
Progesterone for Cannabis Use Disorder: What the New Stress-Response Trial Actually Found
A randomized, placebo-controlled trial in Psychopharmacology tested progesterone in cannabis use disorder and examined sex differences in stress responding. Dr. Caplan reviews this progesterone cannabis use disorder trial and what a hormonal treatment…
Rat Study Links Cannabis Nanoemulsions to Salivary Gland Injury
medical cannabis research: A 21-day rat study found salivary gland tissue changes after oral cannabis nanoemulsions, with isolated CBD producing more injury than CBD plus THC. Human relevance remains uncertain. The main study limits remain important for…
CBG Survey Finds Patient Interest Outpaces Clinical Proof
medical cannabis research: A 239 person survey suggests CBG and CBGA users commonly target sleep, pain, and anxiety, but the evidence remains patient reported and not yet clinically proven. It keeps the evidence readable for patients and clinicians. The…
Cannabis and Tobacco Co-use on the Same Occasion Shows Mixed Acute Effects
medical cannabis research: A systematic review of 18 studies found inconsistent acute cognitive, subjective, and physiological effects when cannabis and tobacco are used during the same occasion. It keeps the evidence readable for patients and…
Cannabinoids for Rheumatoid Arthritis Pain: Promising Signal, Thin Evidence
medical cannabis research: A scoping review found only three clinical studies on cannabinoids for rheumatoid arthritis pain, with one small nabiximols trial showing modest improvements but insufficient evidence for routine use. It keeps the evidence…
Cannabinoids and Autoimmune Disease: What a New Literature Review Says About the Immune Mechanism Gap
A literature review in Revue de Medecine Interne examined the clinical immunomodulatory effects of cannabinoids in autoimmune diseases within internal medicine. Dr. Caplan reviews this cannabinoids autoimmune disease research and the gap between…
Cannabis Use and Poor Mental Health: US Trends, 2016-2023
A study in Social Psychiatry and Psychiatric Epidemiology analyzed trends and disparities in self-reported past-month poor mental health among people who use cannabis in the US from 2016 through 2023. Dr. Caplan reviews this cannabis use mental health…
Endocannabinoid Targets in Endometriosis Pain Need Clinical Testing
medical cannabis research: A new review maps how the endocannabinoid system may influence endometriosis pain through inflammation, nerve sensitization, immune signaling, and lesion biology, while underscoring the absence of definitive clinical trials. It…
Teen Cannabinoid Hyperemesis Complicated by Wernicke Encephalopathy
medical cannabis research: A 15-year-old with chronic cannabis use developed thiamine-deficiency Wernicke encephalopathy after prolonged vomiting from cannabinoid hyperemesis syndrome, improving rapidly after empiric thiamine despite normal brain…
