Pedestrian Trauma Tests Demand Caution About Substance Risk
medical cannabis research: A Houston trauma-center study found frequent alcohol and drug positivity among selectively tested injured pedestrians. Uneven testing, broad drug categories, and missing crash-context data limit conclusions about impairment,…
Cannabinoids and the Aging Brain: Why Dose and Product Type Matter
A review in Frontiers in Pharmacology examined dose-effect complexities and challenges in cannabinoid therapy for aging-related neurobiological changes. Dr. Caplan reviews this cannabinoids aging brain dose research and why the same product can behave…
THC Lowers Peak Eye Pressure, but Glaucoma Benefit Remains Unproven
medical cannabis research: A five-study meta-analysis found a measurable peak eye-pressure reduction after THC, but the control comparison was not statistically significant. These findings do not establish sustained pressure control, vision protection,…
Endocannabinoid System and Opioids: What a New Review Says About Pain and OUD
A review in Expert Opinion on Therapeutic Targets examined therapeutic activation of the endocannabinoid system for opioid use disorder, chronic pain, and cancer-related pain. Dr. Caplan reviews this endocannabinoid system opioid use disorder research…
Autism Animal Studies Suggest New Treatment Targets, Not Proven Patient Therapies
medical cannabis research: A systematic review of 52 animal studies reports behavioral changes after diverse drug and microbiota interventions. The findings identify research directions, but do not establish effective autism treatments, cannabis dosing,…
Cannabinoids and Inflammation: Who Was Studied Matters
medical cannabis research: A reply concerning a cannabinoid and inflammation meta-analysis raises questions about demographic composition and validity. The supplied citation contains no results, so it cannot establish biomarker effects, treatment…
Brain FAAH Binding Rises During Early Cannabis Abstinence in a Small PET Study
medical cannabis research: A small longitudinal PET study found increased brain FAAH binding during early cannabis abstinence. Associations with depression and impulsivity suggest research directions, but the findings do not establish a withdrawal…
NEET Youth Show Higher Tobacco and Cannabis Use in Large Systematic Review
medical cannabis research: A 25 study meta-analysis found that young people not in employment, education, or training had nearly doubled odds of tobacco use and more than doubled odds of current cannabis use. It keeps the evidence readable for patients…
When Adults With ADHD Should Consider Stimulant Deprescribing
medical cannabis research: A psychopharmacology task force used literature review and Delphi consensus to clarify when adult ADHD stimulant deprescribing deserves serious consideration, including misuse, diagnostic uncertainty, absent benefit, and…
Progesterone for Cannabis Use Disorder: What the New Stress-Response Trial Actually Found
A randomized, placebo-controlled trial in Psychopharmacology tested progesterone in cannabis use disorder and examined sex differences in stress responding. Dr. Caplan reviews this progesterone cannabis use disorder trial and what a hormonal treatment…
