Does Low-Dose CBD Get You High? What a New Randomized Trial Actually Found
A randomized crossover trial in the Journal of Psychopharmacology tested the acute behavioral effects of low-dose cannabidiol in healthy volunteers. Dr. Caplan reviews this low dose CBD intoxication RCT and what it actually found about subjective…
CBG, Gut Microbiota, and the Endocannabinoidome in Inflammation and Pain
medical cannabis research: A PubMed-indexed review argues that cannabigerol may influence pain and inflammation through immune, nerve, epithelial, microbiome, and endocannabinoidome pathways, while emphasizing that direct translational evidence remains…
How cannabinoids can amplify threat avoidance through central amygdala circuits
medical cannabis research: A mouse neurobiology study links cannabinoid exposure to stronger threat avoidance, heightened central amygdala somatostatin neuron activity, and altered threat coding, with important cautions for anxiety prone patients. It…
CB2 Activation Calms Inflammatory Gene Signals in Human Gum Fibroblasts
medical cannabis research: A cell-based transcriptomic study suggests the selective CB2 agonist HU-308 reduced IL-1β-driven inflammatory gene expression in human gingival fibroblasts, but it does not prove a periodontal treatment effect in patients. It…
Cannabis Use in Substance Exposed Pregnancy and Postpartum Depression Risk
medical cannabis research: In 255 substance exposed pregnancies, postpartum depression affected 30.19%. Prenatal marijuana use, Black or mixed race identity, and private insurance status were associated with higher documented PPD risk. The main study…
Cannabis Use in Early-Onset Psychosis: What the New Meta-Analysis Shows
A systematic review and meta-analysis in the Journal of the American Academy of Child and Adolescent Psychiatry examined how common cannabis use and cannabis use disorder are in early-onset psychosis, and what they correlate with. Dr. Caplan reviews this…
MAGL Inhibition After Cardiac Arrest Restores Brain Microcirculation in Rats
medical cannabis research: A cardiac arrest study links higher 2-AG and lower arachidonic acid signaling with better neurologic recovery, then shows JZL184 improves survival, memory, edema, and cerebral blood volume in rats. It keeps the evidence…
REVELIO Pilot Study Tests In-Vehicle Detection of Cannabis-Impaired Driving
medical cannabis research: A new German test-track protocol will study whether vehicle data, driver monitoring, wearables, and THC biomarkers can help identify cannabis-related driving impairment in real time. It keeps the evidence readable for patients…
U.S. Child Cannabis Exposures Through 2024: What the New Poison Center Study Shows
A study in the Journal of Addiction Medicine analyzed changes in cannabis exposures among US children age 12 and under from 2000 through 2024. Dr. Caplan reviews this child cannabis exposure poison center data and what has driven the trend, including the…
Topical CBD for Fibromyalgia Pain: What the 12-Week Pilot Actually Found
A 12-week pilot feasibility study in Cannabis and Cannabinoid Research followed 30 women with fibromyalgia using a CBD-containing topical formulation. Dr. Caplan reviews this topical CBD fibromyalgia pilot study, which found improved localized pain and…
