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Relief Is Not the Same as Slowing a Disease: What Cannabis Trials Have Actually Measured
The trials on cannabis and disease progression answer a question patients ask constantly: will this change where my illness is heading, or only make it easier to live with? A three-year randomized trial in progressive multiple sclerosis found no effect…
What Sleep Medicine Guidelines Actually Say About Cannabis, and About the Pills It Gets Compared To
The comparison of cannabis vs prescription sleep aids usually pits cannabis against the two agents sleep medicine explicitly recommends against, which makes it look better than the evidence warrants. Sleep guidelines weakly support eight hypnotics,…
Where Pediatric Cannabinoid Evidence Is Strong, Where It Is Thin, and Where It Does Not Exist At All
Medical cannabis for children has randomized, placebo-controlled evidence in exactly three drug-resistant epilepsy syndromes, using a pharmaceutical cannabidiol preparation under specialist supervision. The largest autism trial reported a null primary…
A Parent’s Guide to Cannabis and Teen Anxiety: What the Research Supports, What It Warns About, and What Actually Treats Adolescent Anxiety
No randomized trial has tested cannabis and teen anxiety together, and the one cannabinoid study in young people was an open-label trial of 31 participants with no control group. Meanwhile a 488-child randomized trial found cognitive behavioral therapy…
What Cannabinoid Receptors Do Inside Immune Cells, and Why That Is Not the Same as Fighting Infection
CB2 receptors and innate immunity are genuinely linked, but not in the way most consumer writing suggests: cannabinoid receptors modulate inflammatory signaling rather than recognizing pathogens. This page separates the established receptor biology from…
THC, CBD, and Cytokine Storms: A Strong Laboratory Signal and One Negative Human Trial
Research on cannabinoids and cytokine storm is real and largely preclinical: cannabidiol and THC reduce inflammatory cytokine output in immune cells and in mouse models of sepsis and lung inflammation. The single randomized placebo-controlled trial in…
Cannabinoid Therapeutics in HIV: Strong Pain Trials, an Appetite Literature From Another Era, and Interaction Data That Has Not Been Updated
The case for cannabis for HIV rests almost entirely on two randomized placebo-controlled trials in HIV-associated sensory neuropathy, where roughly half of treated patients reached a clinically meaningful pain response against a fifth to a quarter on…
Cannabis and Antibiotic Resistance: What Cannabigerol Actually Does to MRSA, and What It Does Not Do in People
The evidence on cannabis and antibiotic resistance is real, reproducible, and entirely preclinical: cannabigerol and cannabidiol inhibit MRSA at low concentrations, clear biofilms, and work in rodent models. Not one human trial has tested a cannabinoid…
Most of What Gets Said About Cannabis and the Gut Microbiome Comes From Mice
Cannabis gut microbiome claims circulate widely, but a systematic review across every clinical condition found only nine human studies, two of which were clinical trials, with effects that varied in direction. The mechanism linking cannabinoid signaling…
Why the Same Edible Behaves Differently on Different Days
Cannabis edible absorption varies several-fold from one evening to the next, and controlled trials have measured which variables are responsible. Dietary fat is the largest lever, raising peak concentration and total exposure substantially while delaying…