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24 Million Americans Microdose Cannabis: What the New National Data Means for Patients and Clinicians
New national survey data show that cannabis microdosing is now the most common form of microdosing in the United States, reported by 9.4 percent of adults. Unlike psilocybin, LSD, or MDMA, cannabis is microdosed primarily for medical reasons such as…
Medical Cannabis Safety Reporting: What a Physician Survey Found
medical cannabis safety reporting: A cross-sectional survey of 253 physicians in Poland found frequent clinical exposure to medical cannabis but limited formal education and uncommon cannabis-specific adverse drug reaction reporting. Knowledge of…
Cannabis Heart Rhythm, Peer-Reviewed at Last: The JACC Data
The peer-reviewed data behind August's cannabis-and-heart-rhythm headlines are finally out. A randomized JACC trial found modestly less cardiac ectopy on cannabis-use days, but the accompanying editorial warns against reading too much into it. Here is…
Cannabinoids and Dementia: New Meta-Analysis Finds No Clear Benefit
cannabinoids dementia meta-analysis: A new systematic review and meta-analysis of nine randomized trials involving 334 participants found no clear improvement in agitation, broader neuropsychiatric symptoms, or cognition with cannabinoid-based…
Cannabis Use Disorder Risk, Internet Use, and Depression: What a Quebec Study Found
cannabis use disorder depression: A cross-sectional Quebec study found that problematic internet use was associated with moderate-to-severe depressive symptoms among adults at high risk for cannabis use disorder. The adjusted association remained after…
Solitary Cannabis Use in Teens: What a Norwegian National Study Found
solitary cannabis use in teens: A national Norwegian study found that 24.3% of high school students reporting past-year cannabis use also reported using alone. Solitary use was associated with more negative consequences across several domains, even after…
Cannabis and Alcohol Co-Use in Sexual-Minority Young Adults: What a National Study Found
cannabis alcohol co-use young adults: A national Monitoring the Future analysis followed 12,173 U.S. young adults and found higher cannabis-use and alcohol-cannabis co-use measures in several sexual-minority subgroups. Gay males and bisexual females had…
Cannabis Use in Cocaine Dependence Treatment: A Randomized Trial of Buprenorphine and Naltrexone
Clinical Takeaway In this study, THC-positive urine drug screens were associated with higher odds of submitting cocaine-positive urine drug screens during treatment for cocaine use disorder. This highlights the importance of addressing polysubstance use…
Cannabinoids in Mental Health Treatment: A Systematic Review of Efficacy and Safety
Clinical Takeaway Cannabinoids show mixed efficacy in treating mental disorders and substance use disorders with varying safety profiles across studies. Limited evidence supports their use as a primary treatment, highlighting the need for further…
Cannabis Sativa Extracts Efficacy in Chronic Low Back Pain: A Phase 3 Trial
Clinical Takeaway VER-01, a full-spectrum extract from Cannabis sativa DKJ127, demonstrated efficacy and safety in treating chronic low back pain compared to placebo. The study showed significant improvements in pain relief and functional outcomes…