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Nabiximols vs. Cannabis Decoction for MS Spasticity: What a New Formulation Comparison Study Found
The nabiximols discontinuation MS spasticity study highlights that most patients eventually stop nabiximols, with some switching to cannabis decoction experiencing further symptom improvement and fewer side effects. This retrospective cohort provides…
Oral Cannabigerol (CBG): What a New Human Safety Study Actually Found
Cannabigerol CBG safety study: a controlled human trial in 12 healthy adults found oral CBG well tolerated up to 200 mg, with no drug-related adverse events, minimal psychoactive effects, and normal liver function tests throughout. It keeps the evidence…
CBD Appears Safe for People Living With HIV on Long-Term Antiretroviral Therapy, New Trial Finds
A new randomized, placebo-controlled trial of 80 adults with long-term virally suppressed HIV finds low-dose full-spectrum CBD safe over 12 weeks, with no meaningful impact on liver, kidney, or viral control markers. Dr. Caplan reviews what the study…
Does Medical Cannabis Mean Lower-Risk Use?
A medical cannabis recommendation can be real and useful, but the label alone does not make cannabis use lower risk. Recent national studies suggest medical and combined medical plus recreational users often use cannabis more frequently, with more…
New National Survey Reveals Cannabis Self-Medication Patterns in Mental Health
A 2026 national survey of 2,400 U.S. adults highlights cannabis self-medication mental health survey patterns, showing links between depression, ADHD, and increased cannabis use disorder risk. The study identifies coping motives like escaping problems,…
Virtual Program Reduces Cannabis and Alcohol Use in Native American Emerging Adults
A culturally grounded virtual substance use intervention significantly reduced cannabis and alcohol use among urban Native American emerging adults. The randomized trial compared two virtual programs and found that only the culturally grounded…
Exploring Digital Cannabis Harm Reduction in First-Episode Psychosis
This analysis examines digital cannabis harm reduction first episode psychosis through the CHAMPS app, highlighting engagement factors and their lack of robust association with improved cannabis outcomes. Higher social support and education influenced…
Smoked Cannabis Across Potencies: What a Controlled Study Found About Sex Differences
smoked cannabis sex differences: A randomized human laboratory experiment exposed 35 adults to placebo and three smoked-cannabis potencies. Females and males reached similar blood THC concentrations and showed few consistent differences across…
Cannabinoid Effects on Substance Use Disorders: Evidence and Insights
This tier-weighted systematic review of 97 studies examines cannabinoid effects substance use disorders, revealing short-term symptom benefits but limited evidence for sustained treatment outcomes. The review highlights that most positive findings come…
Cannabis and Cocaine Use During Treatment: What Urine Testing Found
cannabis and cocaine use during treatment: A secondary analysis of 301 participants in a medication trial found that THC-positive urine tests were associated with higher odds of cocaine-positive tests during eight weeks of treatment. The result supports…