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Telehealth Plus Mobile Monitoring for Cannabis Use Disorder: MOMENT-V Pilot Trial Launches in Young Adults
MOMENT-V cannabis use disorder trial: A newly published protocol describes a 60-participant pilot randomized trial testing a telehealth-plus-mobile-health intervention for cannabis use disorder in young adults treated in primary care. The trial has not…
Does CBD Change How Your Body Handles THC? A New Meta-Analysis Says Yes
This CBD THC pharmacokinetic interaction meta-analysis pooled data from 14 acute dosing trials to reveal that co-administered CBD significantly increases THC's total plasma exposure and its active metabolite levels. The findings highlight a dose-response…
Sleep Disorders in Children With Cerebral Palsy: What a New Systematic Review Found About Melatonin, Cannabis-Based Medicines, and Other Options
This sleep disorders cerebral palsy review summarizes a systematic analysis of 12 randomized controlled trials. Melatonin showed the clearest positive effect on sleep latency and duration in children with cerebral palsy. Cannabis-based medicines and…
Insights from a New Preprint Review on Real-Time Monitoring of Youth Substance Use
A new preprint review of 43 studies highlights real-time monitoring youth substance use using ecological momentary assessment and intervention tools. This approach reveals risk moments and shows promise in reducing harms. The review remains preliminary…
Cannabis Use and the Age-Related Acceleration of Psychosis Onset: What a New 149-Study Meta-Analysis Shows
This meta-analysis of 149 studies examines cannabis use age at onset psychosis, finding users experience psychosis onset 2.50 years earlier than nonusers on average. The age gap widens with increasing age, reaching 6.30 years earlier at 30 and older.…
Emerging Cannabinoid Biosensor Technology for Pain Management
Cannabinoid biosensor technology is evolving to support pain management by enabling measurement of THC and CBD levels. Portable biosensors show promise for point-of-care testing, but most remain unvalidated for clinical use. This review highlights the…
Substance Use and Suicidality in Ultra-High-Risk Psychosis: What 12 Studies Show
This systematic review examines substance use suicidality psychosis in ultra-high-risk populations. It analyzes 12 studies with 2,198 participants, finding limited and inconsistent evidence linking substance use to suicidality. Tobacco showed the most…
Beyond THC and CBD: Insights on Cannabis’s Non-Cannabinoid Compounds
This cannabis non-cannabinoid phytochemicals review synthesizes preclinical evidence on terpenes, flavonoids, and other compounds beyond THC and CBD. It highlights their potential anti-inflammatory, analgesic, and antimicrobial activities and discusses…
Varenicline for Cannabis Use Disorder: What Five Studies Show
Varenicline for cannabis use disorder: A systematic review of five studies involving 299 participants found mixed efficacy and tolerability results. Only one study was rated high quality, and methods were too heterogeneous for meta-analysis. Current…
Insights on Cannabis Craving and Cross-Substance Use from Pooled Trial Data
This pooled analysis of 829 patients examines cannabis craving and cross-substance use, revealing modest, borderline associations with next-week alcohol and cigarette use. The findings highlight the importance of monitoring polysubstance use during…