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Cannabis Legalization Outcomes: What 329 Studies Found
Cannabis legalization outcomes across 329 studies included fewer possession arrests and generally more adult access and use. Youth prevalence did not rise uniformly, but pediatric exposure and acute-care signals remained important. Market and road-safety…
CBD Oil and Autism: What a New Randomized Trial Shows About
CBD oil autism social cognition: A post hoc subanalysis of a randomized, placebo-controlled trial examined CBD-rich cannabis oil's effect on facial expression recognition and theory of mind in 19 children with autism spectrum disorder. Within-group…
THC/CBD Oil for Dementia Agitation: What the MedCanDem
THC CBD oil dementia agitation: The MedCanDem trial, a randomized, placebo-controlled crossover study in 25 nursing home residents with severe dementia, found no significant reduction in agitation on the CMAI scale. The oil significantly lowered…
Cannabis Use Disorder Is Rising Among US Adults
Cannabis use disorder increased among US adult males and females from 2021 through 2024. The national survey also found growth in moderate-to-severe disorder across several age groups. The findings support routine screening but do not identify a cause or…
Social Media Apps and Youth Cannabis Use: What the ABCD
App-specific social media use adolescent cannabis: The ABCD Study reveals that app-specific social media use, particularly Instagram time, is associated with adolescent cannabis use. This observational research highlights how different platforms relate…
Anxiety and Depression, Not Substance Use, Tracked With
A new early schizophrenia anxiety depression study of 170 patients in Northern India found that anxiety and depression significantly correlated with symptom severity. Substance use, including cannabis, tobacco, alcohol, and opioids, did not show a strong…
Cannabinoids for Mental Health and Addiction: What 200
Cannabinoids for mental health were examined across 200 randomized and observational studies. Anxiety and PTSD signals were limited by low certainty, indirectness, and heterogeneity, while depression showed no evident benefit. THC increased withdrawals…
Fenfluramine for Dravet Syndrome: What a New Pooled
This fenfluramine dravet syndrome stratified analysis pools data from three phase 3 trials, demonstrating seizure reduction across most patient subgroups. The study highlights fenfluramine's safety profile and efficacy, providing key insights for…
How a Digital Behavioral Health Game Reduced Depression in Adolescents
A randomized trial of 532 adolescents found that a digital behavioral health game depression adolescents intervention modestly reduced depressive symptoms over 12 months. The study included teens with recent cannabis use but did not measure cannabis…
Endocannabinoid-Glucocorticoid Crosstalk in Pain Resolution
A recent preclinical study demonstrates that endocannabinoid-glucocorticoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes resolution of inflammation-induced hyperalgesia. Researchers observed significant reductions in mechanical and…