| Journal | International immunopharmacology |
| Study Type | Clinical Study |
| Population | Human participants |
This item covers developments relevant to cannabis medicine and clinical practice. Clinicians monitoring evidence in this area should review the source material.
Postoperative delirium (POD) accompanied by sleep disturbances (SD) represents a significant concern in perioperative neurocognitive health. Emerging evidence indicates a potential bidirectional relationship between these conditions; however, their underlying mechanisms remain poorly elucidated, and effective therapeutic interventions are currently lacking. Rhizoma Corydalis (RC), a traditional Chinese medicinal herb recognized for its analgesic and anti-inflammatory properties, has not been previously investigated in the context of cognitive impairment and sleep regulation. This study sought to elucidate the mechanisms by which RC and its bioactive compounds mitigate cognitive deficits and disrupted sleep architecture. This investigation was conducted through a combination of disease-target database mining, bioinformatics analysis, and validation in both in vivo and in vitro models of neuroinflammation. POD and sleep disturbances were identified in subjects through tibial fracture sur
“This is a development worth tracking. The clinical implications will become clearer as more evidence accumulates.”
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This study item was assembled from normalized source metadata and pipeline scoring.
