Cannabinoids and cognition in Parkinson’s disease: Insights from animal models and emerging clinical evidence.
Parkinson's disease (PD) is a progressive, multisystem neurodegenerative disorder characterized not only by motor impairments but also by a broad spectrum of...
Tetrahydrocoptisine alleviates postoperative delirium with sleep disturbances by modulating the TH/NLRP3 Inflammasome pathway.
Postoperative delirium (POD) accompanied by sleep disturbances (SD) represents a significant concern in perioperative neurocognitive health. Emerging evidenc...
Local therapeutic strategies for neurocutaneous dysesthesia: from capsaicin to cannabinoids.
Neurocutaneous dysesthesia (ND) is characterized by abnormal skin sensations such as pruritus or burning without an underlying skin condition. It is caused b...
The quality and scope of health information on online drug platforms: a topic modelling and expert evaluation study of a Polish-language forum.
Determining health information quality on online drug platforms is crucial for revealing and shaping substance use practices. The study aims to assess the sc...
Phenome-Wide Associations of Polygenic Scores for Schizophrenia and Major Depression in 100,000 Chinese Adults.
China faces significant mental health challenges, with unique associations between mental disorders and other traits observed in its population. Based on sum...
Molecular Basis Underlying Changes of Brain Entropy and Couplings in Late-life Depression.
Late-life depression (LLD) with high prevalence accelerates cognitive impairment and becomes a risk factor for dementia, yet the pathogenesis of LLD is still...
Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia.
The relationship between the endocannabinoid system and the emergence and treatment of schizophrenia-related symptoms continues to be a topic of significant ...
Hemp-Derived Extracellular Vesicles: A Novel Frontier in Nanomedicine and Therapeutics.
While mammalian-derived extracellular vesicles (EVs) face significant challenges in clinical translation due to scalability, cost, and safety, plant-derived ...
Polycyclic aromatic hydrocarbons and cannabinoids in secondhand cannabis smoke.
The legalization of cannabis is exposing more people to secondhand smoke (SHS) generated during cannabis use. Given the serious health effects caused by toba...
Cannabigerol induces endoplasmic reticulum stress-mediated apoptosis and ferroptosis via the IRE1α-XBP1 axis in human pancreatic cancer cells.
Cannabigerol (CBG), a non-psychoactive phytocannabinoid derived from Cannabis sativa, has attracted increasing attention owing to its antibiotic, anti-inflam...