| Trial ID | NCT05142267 |
| Status | Recruiting |
| Condition | Opioid Use Disorder |
| Intervention | Placebo |
This trial addresses the critical intersection of stress, pain management, and opioid misuse risk—a gap in our understanding that has profound implications for prescription practices. By examining how stress modulates opioid effects through endogenous opioid and endocannabinoid pathways, it could inform safer prescribing strategies for patients with chronic pain.
NCT05142267 is a recruiting interventional trial investigating stress-induced changes in opioid medication effects among patients with back pain. The study examines how acute stress exposure influences opioid response and misuse potential, with particular focus on endogenous opioid and endocannabinoid system interactions. Primary endpoints likely include subjective drug effects, physiological responses, and behavioral measures of misuse liability under stressed versus non-stressed conditions.
“If this trial demonstrates that stress significantly amplifies opioid misuse risk through measurable biological pathways, I could incorporate stress assessment and mitigation strategies into my pain management protocols. This mechanistic understanding would strengthen my clinical rationale for recommending cannabis-based alternatives in high-stress patients requiring chronic pain management.”
💬 Join the Conversation
Have a question about how this applies to your situation? Ask Dr. Caplan →
Want to discuss this topic with other patients and caregivers? Join the forum discussion →
Have thoughts on this? Share it:
FAQ
This trial item was assembled from normalized source metadata and pipeline scoring.
