A groundbreaking clinical trial is investigating stress induced opioid misuse mechanisms in chronic back pain patients by examining how acute stress modulates endogenous opioid and endocannabinoid systems. This research could identify biomarkers that predict which patients face heightened addiction risk during stressful periods. Understanding these neurobiological pathways may transform how clinicians assess and manage opioid prescribing for vulnerable populations.
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been…
Unpredictable Chronic Mild Stress Upregulates Dopamine Receptor Expression Independent of Fatty Acid-Binding Protein 7 Gene Deletion.
Fatty acid-binding protein 7 (FABP7) assists in the intracellular trafficking of endogenous cannabinoids and polyunsaturated fatty acids (PUFAs) and has been…
West-Asia War | IDF Releases Video: 150 Jets Strike Iran, Targets Missile Infrastructure
✦ New CED Clinical Relevance #70Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. ⚒ Cannabis News | CED Clinic PtsdAnxietyMental HealthStress ResponseSleep Why This MattersMilitary conflicts and geopolitical instability create acute psychological stressors...
Tecan webinar shares insights on salivary cortisol, from collection to confidence
✦ New CED Clinical Relevance #70Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. ⚒ Cannabis News | CED Clinic CortisolHpa AxisStress ResponseBiomarkersEndocrine Why This MattersSalivary cortisol measurement provides a non-invasive method to assess...
Selective upregulation of fatty acid-binding protein 5 within the basolateral amygdala blunts stress-induced reinstatement of cocaine-seeking behavior in mice.
Anandamide (AEA), an endogenous cannabinoid, is thought to exert an inhibitory role in the basolateral amygdala complex (BLA), dampening hypothalamus-pituita…
Personalized resilience: how individual variability in brain-immune responses to stress influences the development of anxiety disorders.
Stress exposure has increased significantly, contributing to higher rates of anxiety, depression, and post-traumatic stress disorder. However, individual res…