This landmark case demonstrates complete radiologic reversal of severe spinal epidural lipomatosis through GLP-1 agonist-induced weight loss combined with medical cannabis pain management. The patient avoided surgical decompression while achieving substantial clinical improvement, suggesting medical weight loss as a potential first-line intervention for obesity-related spinal stenosis.
The toxicology of orally administered ฮ
A toxicology study in Merino ewes demonstrates that oral THC administration produces measurable adverse effects including ataxia and reduced feed intake. These findings highlight important THC toxicity in livestock hemp feed safety considerations for the expanding industrial hemp industry and agricultural applications.
Preventing alcohol and cannabis-impaired driving among adolescents: Effects of a web-intervention in a driver education program.
A randomized trial found that adding a 30-minute web intervention to driver education significantly reduced adolescent intentions for cannabis impaired driving prevention. The intervention worked by changing perceived peer approval of substance use rather than direct behavior modification. This scalable approach leverages existing driver education infrastructure to address adolescent impaired driving risk.
Endocannabinoid System Research and Medical Cannabis Dosing Guide
Clinical Takeaway The April 2026 DEA rescheduling of FDA-approved marijuana products to Schedule III removes federal barriers to prescription cannabis in clinical settings and significantly expands research opportunities previously restricted under Schedule...
The Microbial Mechanisms of Cardiovascular Disease: Oral Dysbiosis as a Systemic Instigator.
This clinical review examines how oral dysbiosis cardiovascular disease mechanisms create systemic inflammation and vascular damage. Evidence shows periodontal therapy can reduce cardiovascular risk markers, establishing oral health as a modifiable risk factor for heart disease prevention.
Daily Temporal Associations Between Use of Psychoactive Substances and Fatigue, Pain, Stress, and Depressive Symptoms in People With Multiple Sclerosis.
A real-time smartphone-based study of 258 MS patients revealed that higher pain levels drive increased cannabis use and decreased alcohol consumption. This research using ecological momentary assessment provides clinical evidence that MS patients make deliberate, symptom-driven substance use decisions throughout their daily lives.
Attitudes, beliefs and willingness to prescribe medical cannabis among public medical practitioners in Malaysia.
A nationwide survey of Malaysian physicians reveals measured acceptance of medical cannabis, with 65% supporting availability for certain conditions. The strongest support emerged for pain management applications, where 87% of doctors endorsed medical cannabis use and 74% would recommend it for cancer pain.
Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties.
Laboratory research has identified prenylated apigenin derivatives from Cannabis sativa with anti-inflammatory properties, representing novel non-psychotropic compounds beyond traditional cannabinoids. While these prenylated apigenin cannabis anti-inflammatory properties show promise in early studies, clinical validation remains necessary. This research expands our understanding of cannabis chemistry and potential therapeutic applications.
Cannabidiol reduces the latency for the behavioral effect of escitalopram in chronically stressed male mice: involvement of NAPE-PLD expressed in parvalbumin-positive interneurons and the prefrontal cortex.
A preclinical study found that CBD accelerates antidepressant effects and enhances SSRI response at lower doses in stressed mice. While promising, these animal findings require clinical validation before informing human treatment protocols.
The effect of daily aerobic cycling exercise on cannabis withdrawal: An inpatient randomised controlled trial.
A randomized controlled trial of 46 adults found that daily aerobic cycling exercise significantly reduced cannabis withdrawal symptom severity during the critical first week of abstinence. This represents the first controlled evidence that aerobic exercise for cannabis withdrawal symptoms may offer a practical, non-pharmacological intervention for cessation support. While promising, larger outpatient studies are needed to establish broader clinical utility.