Neuropathic Pain Severity Linked to Opioid Use in Adults with Traumatic SCI
This study investigates opioid use neuropathic pain spinal cord injury relationships in adults with traumatic SCI. Findings highlight employment as protective against opioid use. Multimodal approaches including cannabis are common in severe neuropathic…
Cannabinoid Clinical Evidence and Its Role in Chronic Pain Management
Current cannabinoid clinical evidence shows modest benefits primarily for neuropathic pain in chronic pain management. The evidence base remains thin with ongoing research gaps. Understanding this cannabinoid clinical evidence is essential for informed…
Assessing Evoked and Spontaneous Pain with Gabapentin and CB2 Receptor Activation
This study investigates neuropathic pain CB2 receptor activation and gabapentin effects on evoked and spontaneous pain. Using a spared nerve injury model, researchers compared pain responses in rats. Findings highlight potential cannabinoid mechanisms…
Cannabis-based interventions might help a little with neuropathic pain – Study Summary
Cannabis neuropathic pain relief shows modest improvements in patients with challenging neuropathic pain. Studies reveal small to moderate benefits from cannabis-based interventions. This evidence supports cautious use as adjunct therapy for neuropathic…
Honoring the Trailblazers with MS Who Changed Cannabis Policy
Multiple sclerosis cannabis advocacy has played a pivotal role in shaping medical cannabis policy. MS patients were among the first to demonstrate therapeutic benefits of cannabinoids in clinical settings. Their efforts helped establish evidence-based…
Opioids and Cannabinoids for Neurologic Pain: What Neurologists Need to Know in 2024
This 2024 CME review focuses on opioid therapy neurologic pain, synthesizing current evidence and guidelines for neurologists. It highlights risks of abrupt opioid tapering and the investigational role of cannabinoids. The review supports a cautious,…
Local Therapeutic Strategies for Neurocutaneous Dysesthesia: From Capsaicin to Cannabinoids
Local therapeutic strategies neurocutaneous dysesthesia focus on topical treatments such as capsaicin and cannabinoids to manage abnormal skin sensations. These approaches provide targeted relief with fewer systemic effects. This review highlights…
Targeting Molecular Pathways in Neuropathic Cancer Pain: From Mechanisms to Novel Therapeutics
Neuropathic cancer pain management remains a significant clinical challenge due to its complex molecular pathways. Emerging therapeutics targeting these pathways offer new hope for relief. This review highlights advances in neuropathic cancer pain…
Cannabis-based medicines for chronic neuropathic pain in adults.
Estimates of chronic neuropathic pain affect 6% to 10% of adults. Cannabis-based medicines for chronic neuropathic pain offer a potential treatment option when conventional therapies fail. Current evidence suggests modest benefits with important safety…
Cannabis Oil Did Not Meaningfully Reduce Pain in Nerve-Injury Patients, Rigorous Trial Finds
This cannabis brachial plexus pain RCT found cannabis-based medicine did not improve pain by a clinically important margin. The study advises against adding cannabis oil to standard pain treatment for traumatic brachial plexus injury. Sleep quality…