? While this collection of 12 cannabis articles did not meet the threshold for high clinical relevance, collectively they reflect the ongoing fragmentation of cannabis research across diverse populations, dosing regimens, and outcome measures, making it difficult to synthesize actionable guidance for clinical practice. The heterogeneity in study designs, sample sizes, and outcome definitions creates a landscape where individual studies may examine interesting phenomena but lack sufficient rigor or generalizability to shift clinical recommendations, and publication bias toward positive findings further complicates interpretation. Clinicians should remain cautious about extrapolating findings from lower-evidence studies to their own patient populations, particularly given the variable regulatory status of cannabis products and the persistent gaps in long-term safety data across age groups and comorbid conditions. Rather than waiting for the perfect evidence base, which may take years to develop, a practical approach involves documenting cannabis use patterns in your patient encounters, engaging in shared decision-making conversations

Clinical Perspective

These items reflect an emerging pattern of clinical education materials prioritizing cannabis-related conditions that warrant routine practitioner awareness. The highlighted topics—including cannabinoid hyperemesis syndrome and prenatal exposure risks—represent conditions with clear clinical presentations and management implications that should inform standard patient assessment. This educational trend underscores the field’s movement toward evidence-based clinical guidance as cannabis use becomes increasingly prevalent in patient populations.