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CBD Probably Reduces Seizures in Refractory Epilepsy, But Raises Risk of Serious Adverse Events
Cannabidiol treatment resistant epilepsy shows probable seizure reduction benefits at 10 and 20 mg/kg/day doses. However, cannabidiol treatment resistant epilepsy also raises the risk of serious adverse events. This systematic review highlights the need…
Expert Commentary on Cannabis Trial for Brachial Plexus Pain
This expert commentary reviews a cannabis brachial plexus neuropathic pain trial showing no significant benefit. The findings help guide clinicians in managing expectations. Continued research into neuropathic pain mechanisms remains essential.
Brief Online Mindfulness Program Did Not Reduce Cannabis Use in Small Randomised Trial
A brief online mindfulness program cannabis use disorder trial found no significant benefit in reducing cannabis use. The study involved 66 adults and showed no effect on cannabis frequency or cravings. These null findings highlight the need for more…
Small Pilot Trial Finds Medicinal Cannabis Feasible to Study in Adolescents with Tourette Syndrome — But Efficacy Remains Unknown
This pilot trial medicinal cannabis adolescents study demonstrates that a rigorous crossover trial is feasible and acceptable for Tourette Syndrome. The study confirms protocol adherence and family willingness but does not establish efficacy. A fully…
Pilot Study Finds Salivary Metabolite Shifts in Autistic Children Treated with Medical Cannabis—But Evidence Remains Preliminary
This pilot study explores salivary metabolomics autism cannabis shifts in children with ASD after treatment. It identifies 65 candidate biomarkers but remains preliminary due to study limitations. Larger controlled trials are needed to confirm these…
Comprehensive Guide to Endocannabinoid System Clinical Research
This endocannabinoid system clinical research guide highlights genetic variants linked to psychiatric disorders. The study identifies key SNPs in the DAGLA gene associated with mental health risks. Understanding these findings aids in contextualizing the…
Rigorous CBD Trial for Autism Behavioral Symptoms Launches—But Results Are Not Yet In
The CASCADE CBD autism trial protocol 2024 outlines a rigorous placebo-controlled crossover study of pharmaceutical cannabidiol for irritability and aggression in children with autism spectrum disorder. This trial addresses critical gaps by using…
Cannabis Added to Standard Pain Medications Did Not Reach Clinically Meaningful Pain Relief in Brachial Plexus Injury
The cannabis brachial plexus injury pain trial found a statistically significant but clinically insufficient pain reduction. Cannabis-based medicine did not improve pain by a clinically important margin. Sleep quality improved modestly, suggesting…
Australian Trial to Test Whether Cannabis Can Prevent Chemotherapy Gut Damage: Protocol Published
The cannabis chemotherapy mucositis trial is the first rigorous study testing combined CBD and THC to prevent chemotherapy-induced gut damage. This protocol outlines the design of a phase II randomized controlled trial focused on gastrointestinal…
Cannabidiol Probably Reduces Seizures in Drug-Resistant Epilepsy—But Serious Side Effects Also Rise
The cannabidiol pediatric epilepsy dosing 2025 review shows that pharmaceutical-grade cannabidiol probably reduces seizures in treatment-resistant epilepsy. This review highlights a meaningful benefit-risk trade-off with increased serious adverse events…