Prenatal THC exposure and binge-like alcohol drinking in early adolescence: From sex-specific drinking vulnerability to abnormal endocannabinoid-dopamine nexus in the nucleus accumbens.
Preclinical research reveals that prenatal THC exposure disrupts developing brain reward circuits and increases adolescent alcohol drinking vulnerability through sex-specific changes in endocannabinoid-dopamine signaling. These findings support clinical…
Cannabidiol and diabetic heart disease: Mechanistic evidence and translational challenges.
New preclinical research reveals CBD's potential to address multiple pathways in diabetic heart disease, including inflammation and oxidative stress. However, the cbd diabetic heart disease preclinical evidence requires human clinical trials before any…
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Research validates meconium cannabis testing pregnancy detection as more sensitive than maternal urine for identifying third trimester cannabis exposure. This forensic methodology study provides clinicians with improved detection capabilities for…
Cannabidiphorol (CBDP) acts as a negative allosteric modulator at two distinct sites of cannabinoid receptor 1.
Recent research demonstrates that cannabidiphorol (CBDP) acts as a negative allosteric modulator at CB1 receptors through a novel dual-site mechanism. This finding suggests CBDP could potentially provide therapeutic cannabinoid system modulation without…
Demographic features, health status, and behavioral changes associated with cannabidiol use in the Dog Aging Project.
The Dog Aging Project's survey of over 20,000 dog owners provides the first large-scale analysis of CBD use patterns in companion dogs study, revealing how owner demographics and perceived health needs drive cannabidiol administration decisions. While…
Evidence-based consensus guidelines for the pharmacological management of substance dependence: Recommendations from the British Association for Psychopharmacology.
New expert consensus guidelines include evidence-based recommendations for cannabis use disorder treatment alongside other substance dependencies. The British Association for Psychopharmacology guidelines provide clinicians with systematic approaches to…
Acute toxicity of ADB-CHMINACA – a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome.
A new case series reveals that synthetic cannabinoid toxicity emergency treatment protocols are urgently needed as ADB-CHMINACA causes rapid-onset seizures and encephalopathy. Emergency physicians document severe neurologic complications occurring within…
Cannabis modalities matter for momentary subjective drug effects.
A new ecological momentary assessment study reveals that cannabis consumption method subjective effects vary significantly between delivery mechanisms. Researchers found vaporizers produced less subjective intoxication while bongs were associated with…
Cannabis Products and Contaminant Detection: Critical Review of Regulatory Oversight and Analytical Methodologies.
A comprehensive review of cannabis contaminant testing regulatory inconsistencies reveals significant gaps in safety oversight across U.S. jurisdictions. This analysis highlights critical patient safety concerns stemming from variable testing standards…
Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia.
The relationship between the endocannabinoid system and the emergence and treatment of schizophrenia-related symptoms continues to be a topic of significant ...