“Dr. Caplan’s handbook is an essential, compassionate guide that cuts through decades of stigma. It gives patients the scientific tools, dosing clarity, and confidence they need to take charge of their own healing.”

“Having led the Massachusetts Cannabis Control Commission, I witnessed firsthand the urgent need for credible, physician-led education. Dr. Caplan provides exactly that—grounded in rigorous science and deep patient empathy.”

“Dr. Caplan bridges the gap between molecular biochemistry and clinical reality. This handbook is required reading for any doctor, healthcare provider, or patient seeking evidence-based cannabinoid medicine.”

“Thirty-five years after the DEA ruled marijuana is ‘one of the safest therapeutically active substances known to man,’ Dr. Benjamin Caplan affirms such in his comprehensive, scholarly work.”

“The first comprehensive medical guide that provides groundbreaking new solutions to many of the medical issues that affect us all: anxiety, insomnia, and chronic pain.”

“Dr. Caplan brings clinical rigor, Boston medical excellence, and unmatched patient clarity to an industry that sorely needed standard-setting leadership.”

The Endocannabinoid Foundation

How CB1 and CB2 receptors modulate homeostasis across the nervous, immune, digestive, and cardiovascular systems.

Microdosing & The Therapeutic Window

Finding the exact biphasic inflection point where symptom relief peaks before tolerance or adverse sedation emerges.

Cannabinoid & Terpene Synergy

The entourage effect demystified: how myrcene, beta-caryophyllene, pinene, and limonene alter bioavailability.

Targeted Protocols for Pain & Sleep

Dosing strategies replacing opioids and benzodiazepines for inflammatory neuropathies, insomnia, and fibromyalgia.

Oncology & Chemotherapy Support

Managing chemotherapy-induced nausea (CINV), cachexia, somatic pain, and emotional trauma during recovery.

Geriatric Dosing & Medication Safety

Polypharmacy considerations, CYP450 liver metabolic interactions, and fall prevention protocols for older adults.