Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement.
Oral cannabinoid bioavailability remains a significant clinical challenge due to first-pass metabolism. Oral mucosal delivery systems improve absorption by bypassing hepatic metabolism. These approaches offer more predictable dosing and enhanced…
Results of an Exploratory Crossover Pharmacokinetic Study Evaluating a Natural Hemp Extract-Based Cosmetic Product
This crossover pharmacokinetic study evaluates topical hemp pharmacokinetics and systemic absorption of cannabinoids from a natural hemp extract cosmetic product. It compares bioavailability between topical and oral routes of administration in human…
A simple, sensitive and rapid bioanalytical method for quantifying cannabidiol (CBD), 7-OH-CBD and 7-COOH-CBD in human plasma.
This bioanalytical method cannabidiol plasma quantification provides reliable measurement of CBD and its metabolites in human plasma. Accurate plasma quantification is essential for pharmacokinetic studies and therapeutic monitoring. The method is…
Virginia Officials Launch Campaign Against Driving Under Influence of Marijuana
Virginia marijuana impaired driving is a growing public safety concern addressed by a new campaign. This initiative focuses on improving awareness and detection of cannabis impairment. Patients need clear guidance on driving safety related to marijuana…
Pharmacokinetic and Pharmacodynamic Properties of Cannabigerol in Male Mice
This study investigates the pharmacokinetic properties of cannabigerol in male mice, highlighting its brain penetration and metabolite accumulation. Findings reveal unexpected anxiogenic effects at peak brain concentrations. Understanding these…
New Insights on Cannabis Liver Interactions from Recent Study
Cannabis liver interactions are critical for understanding hepatic metabolism and drug safety. This study highlights how cannabis compounds affect liver enzyme systems. Clinicians should monitor liver function closely when patients use cannabis…
University of Calgary Scientists Study Optimal THC Dosage for Therapeutic Use
THC dosing clinical research addresses the challenge of standardizing therapeutic windows for cannabis treatment. University of Calgary scientists study optimal THC dosage to improve clinical protocols. This research aims to provide evidence-based…
Bill regulating THC drinks and gummies clears key hurdle in South Carolina Senate
THC edible regulation South Carolina is progressing to address safety and labeling concerns for cannabis-infused beverages and gummies. This regulatory framework aims to reduce accidental overdoses and improve patient counseling. Clinicians should stay…
Vaping Linked to Faster Onset of Cannabis Disorder: Study Insights
A recent study highlights vaping cannabis disorder leads to a faster onset of dependence than other methods. Vaped cannabis reaches the brain more rapidly, increasing addiction risk. Clinicians should counsel patients on vaping cannabis disorder risks…
Older Cannabis Users: Benefits for Dispensaries, Concerns for Doctors
Older adults cannabis dosing safety is a growing concern as this demographic increasingly uses cannabis. Clinicians face challenges due to limited safety data and drug interactions. Understanding these issues is vital for appropriate patient counseling.
