The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by acti
Rheumatoid arthritis (RA) is a very common chronic disease affecting many joints, most noticeably those in the hands and feet. It occurs when the body’s immune system attacks its own tissues that make up the joints, causing damage and consequently, pain.…
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
Invasion and metastasis of aggressive breast cancer cells to other organs is the final and fatal step during cancer progression. Recently, the Id-1 protein was found to be abnormally overexpressed and to serve as a key promoter of the metastatic…
The potential application of the cannabinoid Beta-caryophyllene in glioblastoma therapy
Beta-Caryophyllene Inhibits Cell Proliferation through a Direct Modulation of CB2 Receptors in Glioblastoma Cells In Summary Glioblastoma (GBM) is an aggressive type of cancer of the brain and spinal cord, arising from cells called astrocytes, which…
Activation of the cannabinoid receptor type 2 reduce damages to the brain and disruptions to the spinal cord during ischemia-reperfusion injury
Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model In Summary Ischemia is the restriction in blood supply, causing a shortage of oxygen and resulting in damage to the tissue.…
The endocannabinoid system controls various functions of the olfactory circuit
Cannabinoid Control of Olfactory Processes: The Where Matters In Summary: Cannabis exerts its mental and physical effects by producing chemicals called cannabinoids. In mammalian, the endocannabinoid system (ECS) include cannabinoid receptors type 1…
The Dietary Flavonoid, Luteolin, Negatively Affects Neuronal Differentiation
In Summary: The Importance of Chemical Structure: Functional Groups of Flavonoids A recent study has revealed the detrimental effects of the flavonoid luteolin on neuronal differentiation in embryonic stem cells. Luteolin is a dietary flavonoid that has…