How cannabinoids can amplify threat avoidance through central amygdala circuits
medical cannabis research: A mouse neurobiology study links cannabinoid exposure to stronger threat avoidance, heightened central amygdala somatostatin neuron activity, and altered threat coding, with important cautions for anxiety prone patients. It…
CB2 Activation Calms Inflammatory Gene Signals in Human Gum Fibroblasts
medical cannabis research: A cell-based transcriptomic study suggests the selective CB2 agonist HU-308 reduced IL-1β-driven inflammatory gene expression in human gingival fibroblasts, but it does not prove a periodontal treatment effect in patients. It…
Cannabis Use in Substance Exposed Pregnancy and Postpartum Depression Risk
medical cannabis research: In 255 substance exposed pregnancies, postpartum depression affected 30.19%. Prenatal marijuana use, Black or mixed race identity, and private insurance status were associated with higher documented PPD risk. The main study…
MAGL Inhibition After Cardiac Arrest Restores Brain Microcirculation in Rats
medical cannabis research: A cardiac arrest study links higher 2-AG and lower arachidonic acid signaling with better neurologic recovery, then shows JZL184 improves survival, memory, edema, and cerebral blood volume in rats. It keeps the evidence…
REVELIO Pilot Study Tests In-Vehicle Detection of Cannabis-Impaired Driving
medical cannabis research: A new German test-track protocol will study whether vehicle data, driver monitoring, wearables, and THC biomarkers can help identify cannabis-related driving impairment in real time. It keeps the evidence readable for patients…
Cannabis Use and Early Psychiatric Rehospitalization in Young Adults With Bipolar or Psychotic Disorders
medical cannabis research: A 200-patient historical cohort links cannabis use at psychiatric admission with higher early readmission risk, especially during the first month after discharge. It keeps the evidence readable for patients and clinicians. The…
THC and Social Behavior in Rodents Shows Dose, Timing, and Model Dependence
medical cannabis research: A systematic review of 49 rodent studies found THC often reduced normal social behavior, while low doses sometimes improved deficits in selected impairment models, with reporting quality limiting confidence. It keeps the…
Frequent Cannabis Use Linked With Higher Seizure Burden in Drug-Resistant Epilepsy
medical cannabis research: A small EMU cohort found frequent cannabis users with drug-resistant epilepsy had more focal to bilateral tonic-clonic seizures and greater medication burden, but the study cannot prove cannabis caused worse epilepsy. It keeps…
Virtual Family Coaching for Young Teens at Substance Use Risk Shows Feasibility, Not Proven Prevention
medical cannabis research: A tiny single-arm pilot found that a virtual 2-hour family session was acceptable and mostly completed, but it cannot yet prove reductions in teen cannabis, alcohol, tobacco use, or SUD risk. It keeps the evidence readable for…
New Headache Drug Targets Beyond CGRP: PACAP, Endocannabinoids, Sex Specific Pathways, and More
medical cannabis research: A 2025 narrative review maps emerging headache therapies beyond CGRP, including PACAP antibodies, endocannabinoid modulation, prolactin, orexin, PAR2, and nitroxidative stress targets. It keeps the evidence readable for…
