Blog: What Cannabinoid Safety for Autistic Children Requires
Cannabinoid safety for autistic children requires more precision than broad claims about cannabis and autism. Randomized trials of purified CBD and CBD-dominant formulations have produced mixed results, including negative primary outcomes alongside…
CBD for Pericarditis: What the New JAHA Trial Shows
CBD for recurrent pericarditis produced early pain and inflammation signals in a 27-person Phase II pilot trial. Most participants entering the extension remained recurrence-free while standard medications were tapered, but the study had no placebo group…
CBD for Severe Autism: What a 27-Month Study Found
A new long-term observational study published in Pharmacology Biochemistry and Behavior followed children with severe autism spectrum disorder on purified CBD for an average of 27.6 months. Improvements seen at three months were maintained, and 40% of…
Cannabidiol Urine Concentrations in Athletes: Effects of Daily Use and Exercise
CBD urine concentrations in athletes climbed to detectable levels after just ten weeks of daily broad-spectrum supplement use at 150 mg per day. Exercise further amplified the effect, raising the risk that trace cannabinoids like CBG and CBDV would…
Cannabidiol Effects on Glutamate and Learning in Psychosis Prevention
Cannabidiol clinical trials psychosis research reveal that a single dose of CBD modulates hippocampal glutamate and prefrontal activation during memory tasks. This suggests CBD's potential to normalize disrupted brain circuitry in early psychosis. These…
Endocannabinoid System Research: Cannabidiol’s Impact on Glucose Tolerance & Gut Health in Obese Adults
This pilot study examined cannabidiol gut microbiome obesity effects and found no significant improvement in glucose tolerance in sedentary overweight adults. While animal studies suggested metabolic benefits, these were not replicated here. Larger…
Cannabidiol Effects on Cortical Excitability: Evidence from a Randomized, Double-Blind, Placebo-Controlled Study
This clinical trial evaluated CBD anti seizure activity and found no direct effect on cortical excitability or sedation in healthy adults. The study suggests CBD's benefit may depend on interactions with other drugs like clobazam. These findings…
Cannabis Dosing in Family Medicine: Evidence-Based Care for Endocannabinoid System Regulation
CBD dominant edibles anxiety relief shows significant promise in reducing anxiety symptoms. Cannabis dosing for anxiety varies by product type and cannabinoid composition. This evidence-based approach supports family medicine care focused on…
How CBD Interfered With HIV Entry Across Multiple Immune Cells
CBD HIV transmission prevention research published in Mucosal Immunology found that cannabidiol disrupted HIV-1 infection across multiple immune cell populations in laboratory and human tissue models. Researchers at Institut Cochin identified a…
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
A narrative review examines how CBD hyperarousal insomnia mechanistic pathways may involve endocannabinoid, inflammatory, and autonomic system modulation. While mechanistically plausible, this theoretical framework requires clinical validation before…