CBD for Severe Autism: What a 27-Month Study Found
A new long-term observational study published in Pharmacology Biochemistry and Behavior followed children with severe autism spectrum disorder on purified CBD for an average of 27.6 months. Improvements seen at three months were maintained, and 40% of…
Cannabidiol Urine Concentrations in Athletes: Effects of Daily Use and Exercise
Clinical Takeaway Athletes using broad-spectrum CBD supplements risk testing positive for WADA-prohibited cannabinoids such as CBG and CBDV, even when the product contains only trace amounts of these compounds. Ten weeks of daily use at 150 mg per day…
Cannabidiol Effects on Glutamate and Learning in Psychosis Prevention
Clinical Takeaway In a study of individuals at clinical high risk for psychosis, a single dose of CBD was shown to modulate the relationship between hippocampal glutamate levels and prefrontal brain activation during verbal memory tasks. This suggests…
Endocannabinoid System Research: Cannabidiol’s Impact on Glucose Tolerance & Gut Health in Obese Adults
This pilot study examined cannabidiol gut microbiome obesity effects and found no significant improvement in glucose tolerance in sedentary overweight adults. While animal studies suggested metabolic benefits, these were not replicated here. Larger…
Cannabidiol Effects on Cortical Excitability: Evidence from a Randomized, Double-Blind, Placebo-Controlled Study
This clinical trial evaluated CBD anti seizure activity and found no direct effect on cortical excitability or sedation in healthy adults. The study suggests CBD's benefit may depend on interactions with other drugs like clobazam. These findings…
Cannabis Dosing in Family Medicine: Evidence-Based Care for Endocannabinoid System Regulation
CBD dominant edibles anxiety relief shows significant promise in reducing anxiety symptoms. Cannabis dosing for anxiety varies by product type and cannabinoid composition. This evidence-based approach supports family medicine care focused on…
How CBD Interfered With HIV Entry Across Multiple Immune Cells
CBD HIV transmission prevention research published in Mucosal Immunology found that cannabidiol disrupted HIV-1 infection across multiple immune cell populations in laboratory and human tissue models. Researchers at Institut Cochin identified a…
Mechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
A narrative review examines how CBD hyperarousal insomnia mechanistic pathways may involve endocannabinoid, inflammatory, and autonomic system modulation. While mechanistically plausible, this theoretical framework requires clinical validation before…
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru
This study on cbd powder formulation pharmacokinetics reveals comparable bioavailability to traditional oil-based CBD products. It highlights formulation-dependent food effects on absorption in healthy adults. While bioequivalence is established,…
The effects of cannabidiol on sleep disturbances within a sample of high trait worriers: A double-blind, randomized placebo controlled trial.
This CBD sleep disturbances trial investigates cannabidiol's effects on sleep in individuals with high trait worry. The study is a double-blind, randomized placebo controlled trial. It provides important insights into CBD's role in managing sleep…