Outpacing Emerging Drug Threats: Validation of ToxBox Kits That Automate LC-MS/MS Analyses.
Automated LC-MS/MS testing platforms successfully validated cannabinoid detection alongside other substances in public health overdose surveillance programs. This technology enables real-time monitoring of polysubstance use patterns involving cannabis,…
Drugs detected in suspected pediatric exposures: a 5-year review.
A 5-year hospital study found pediatric cannabis exposure emergency department detection patterns showing cannabis metabolites among the most frequently identified compounds in children presenting with suspected toxic ingestions. This surveillance data…
Therapeutic potential and pharmacological mechanisms of cannabinoids in alleviating chemotherapy-induced organ toxicity and adverse effects.
A comprehensive review examines how cannabinoids chemotherapy organ protection mechanisms could address treatment-limiting toxicities. While theoretical evidence suggests promise through anti-inflammatory and antioxidant pathways, clinical validation…
Cannabinoid Effects of Metamizol/Dipyrone: A Possible Second Life in Pediatric Anesthesia for a Vintage Drug.
Recent research demonstrates that metamizol/dipyrone exhibits cannabinoid effects in pediatric anesthesia applications, revealing endocannabinoid system interactions. This study provides mechanistic insights into how this vintage analgesic may achieve…
LINC01996 suppresses non-small cell lung cancer proliferation and metastasis by orchestrating the miR-12115/CNRIP1/Ras signaling axis.
Preclinical research identifies CNRIP1 cannabinoid receptor protein as a tumor suppressor in lung cancer models. This laboratory study reveals new mechanisms of endocannabinoid system proteins in cancer biology, though clinical applications remain…
Drug policy and culture: A cross-national comparative study using Hofstede’s index.
Cross-national analysis of 25 countries reveals that cultural factors in cannabis policy significantly influence national drug policy frameworks. Countries with lower power distance and uncertainty avoidance demonstrate more progressive approaches to…
Alcohol quantity mediates the association between daily alcohol and cannabis co-use and alcohol consequences.
Recent research on cannabis alcohol co-use consequences shows that alcohol quantity, rather than substance interactions, mediates increased alcohol-related problems. This finding supports quantity-focused harm reduction approaches for patients who co-use…
Hidden nicotine: Cotinine levels among young adult Black men who smoke cannabis blunts.
A new study reveals that over half of young adults using cannabis blunts have measurable nicotine exposure despite reporting no tobacco use. This research highlights the hidden nicotine exposure cannabis blunts may contain and its clinical implications…
Do Cannabis Users Require More Anesthesia During Third Molar Removal Under Intravenous General Anesthesia When Compared to Nonusers?
A prospective study found that cannabis users with 2-3 years of regular use required significantly higher propofol doses during third molar surgery. This research provides evidence-based risk stratification for cannabis anesthesia requirements oral…
Prepregnancy Care and Counseling: A Review.
A new JAMA review places cannabis cessation before pregnancy alongside established interventions like folic acid supplementation and tobacco cessation. This authoritative guidance reflects medical consensus that cannabis cessation before pregnancy should…
