Cannabinoids Show Modest, Low-Certainty Benefits for a Few Mental Health Conditions—But Widespread Clinical Use Is Not Justified
This 2026 review examines cannabinoids mental health benefits, revealing modest effects for select conditions. Evidence remains limited and of low certainty. Routine clinical use is not justified without further trials.
Nearly 4 in 10 Young Lung Cancer Patients Also Smoked Cannabis—and Their Cancers Were More Aggressive
Cannabis tobacco dual smoking lung cancer is linked to more aggressive tumors in young patients. A French cohort study found nearly 4 in 10 young lung cancer patients smoked both substances. This dual smoking group showed earlier diagnosis and higher…
Inhaled CBD Reduces Key Neuroinflammatory Markers in Alzheimer’s Mouse Model
Inhaled cannabidiol neuroinflammation effects were studied in an Alzheimer's mouse model, showing reduced IDO and cGAS expression. This reduction correlated with decreased proinflammatory cytokines. These findings highlight inhaled cannabidiol…
Cannabinoids and cognition in Parkinson’s disease: Insights from animal models and emerging clinical evidence.
Cannabinoids and cognition in Parkinson's disease are increasingly studied due to the endocannabinoid system's role in neural circuits affected by PD. Animal models show promising neuroprotective and cognition-preserving effects of cannabinoids. However,…
Enhancing Endocannabinoid System for Residual Disease in MS
This clinical study endocannabinoid system approach addresses residual disease in relapse-free multiple sclerosis patients. High-efficacy therapies reduce relapses but symptoms persist. Enhancing the endocannabinoid system offers new treatment insights.
Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.
The LPI GPR55 receptor axis plays a crucial role in metabolic dysfunction-associated fatty liver disease (MAFLD). This pathway contributes to liver fat accumulation, inflammation, and fibrosis. Understanding this axis offers novel insights into potential…
Cannabinoids in Combination with Conventional Breast Cancer Therapies: Mechanistic Insights and the Gap to Clinical Translation.
This review highlights cannabinoid anti-tumor effects breast cancer research and its potential to enhance conventional therapies. It emphasizes the gap between preclinical findings and clinical translation. Understanding these effects is crucial for…
Pharmacokinetic and Pharmacodynamic Properties of Cannabigerol in Male Mice
This study investigates the pharmacokinetic properties of cannabigerol in male mice, highlighting its brain penetration and metabolite accumulation. Findings reveal unexpected anxiogenic effects at peak brain concentrations. Understanding these…
Cannabidiol in Epilepsy: Restoring Locomotion and Seizure Control
CBD motor function treatment-resistant epilepsy research highlights its potential to improve seizure control while preserving motor abilities. This dual impact addresses a critical gap in epilepsy management. Patients with treatment-resistant epilepsy…
Personalized Resilience: Variability in Brain-Immune Stress Responses
Brain-immune responses to stress vary significantly among individuals, influencing anxiety disorder development. This variability affects HPA axis regulation and immune function. Understanding these responses is key to personalized resilience strategies.