Distribution and Modulation of Endocannabinoid Enzymes in Post-Traumatic Headache
Post-traumatic headache endocannabinoid system changes are critical in understanding pain after mild traumatic brain injury. This study maps enzyme distribution in trigeminal and midbrain regions. Findings provide a foundation for potential…
Astrocytic GPR55 receptors promote glycolysis.
Astrocytic GPR55 receptors play a key role in promoting glycolysis, the process of sugar metabolism in brain cells. This receptor influences brain energy metabolism and supports neural function. Understanding astrocytic GPR55 receptors helps clarify…
Anti-inflammatory effects of Glehnia littoralis ethyl acetate extract and its active compound phellopterin via inhibition of N-acylethanolamine acid amidase.
Glehnia littoralis anti-inflammatory properties are linked to inhibition of N-acylethanolamine acid amidase (NAAA). The ethyl acetate extract and phellopterin compound show promising anti-inflammatory effects. This research highlights potential…
Targeting CB1 and TRPM8 Receptors to Counteract CD8+ T Cell Exhaustion
This study highlights the role of cb1 receptor antagonist cancer immunotherapy in reducing exhaustion markers on CD8+ T cells. Blocking CB1 receptors may help maintain T cell function against tumors. These findings suggest potential benefits of CB1…
An Adapted Brief Negotiation Interview for Alcohol and Cannabis Use Among Assault-Injured Emerging Adults: A Randomized Pilot Trial Protocol
Emerging adults are disproportionately at risk for substance misuse and assault injury. This study focuses on assault-injured emerging adults substance use, adapting a brief negotiation interview. It aims to improve intervention strategies in emergency…
Daily Temporal Associations Between Psychoactive Substance Use and MS Symptoms
This study investigates psychoactive substance use multiple sclerosis patients experience daily. Using ecological momentary assessment, it tracks symptom fluctuations and substance use patterns. Findings reveal complex, symptom-dependent relationships…
Trends in Cannabis Urine Drug Screen Testing in Colorado’s Largest Health System
This study examines cannabis urine drug screen testing trends in Colorado's largest health system. It highlights demographic disparities in testing practices. Cannabis urine drug screen testing rates and positivity have shifted significantly since…
Cannabis and Schizophrenia: Meta-Analysis Finds Roughly Threefold Risk Elevation, but Causation Remains Contested
The cannabis schizophrenia risk meta-analysis reveals a significant association between cannabis use and increased schizophrenia risk. This risk is especially pronounced with adolescent use and high-THC products. However, causation remains contested due…
Cannabinoids Show Promise for Chronic Pain, But Evidence Remains Thin
The cannabinoids chronic pain evidence review reveals moderate efficacy signals across several conditions but highlights the low quality of current studies. While cannabinoids show promise, the evidence remains thin due to small sample sizes and short…
Cannabis Users Need More Propofol, But Confounders Cloud the Evidence
Cannabis anesthesia requirements are increasingly relevant as cannabis use rises among surgical patients. This meta-analysis finds cannabis users require more propofol, but confounders like age and tobacco use complicate interpretation. Understanding…
