Most of What Gets Said About Cannabis and the Gut Microbiome Comes From Mice
Cannabis gut microbiome claims circulate widely, but a systematic review across every clinical condition found only nine human studies, two of which were clinical trials, with effects that varied in direction. The mechanism linking cannabinoid signaling…
Why the Same Edible Behaves Differently on Different Days
Cannabis edible absorption varies several-fold from one evening to the next, and controlled trials have measured which variables are responsible. Dietary fat is the largest lever, raising peak concentration and total exposure substantially while delaying…
Which Cannabis Compounds Have Been Tested for Gut Problems, and What the Trials Found About Symptoms Versus Inflammation
Cannabis for gastrointestinal symptoms has been tested more carefully than most cannabis indications, and four randomized trials in Crohn's disease and ulcerative colitis produced the same uncomfortable result: symptom scores and quality of life improved…
The Skin Has Its Own Cannabinoid Receptors. That Is Not the Same as Topicals Working.
The skin endocannabinoid system is documented anatomy, with CB1 and CB2 receptors mapped to keratinocytes, sebocytes, hair follicles, sweat glands, sensory nerves, mast cells, and macrophages in human tissue. That receptor map is the most common…
Parkinson’s, Alzheimer’s, Huntington’s and ALS: What Cannabis Has Actually Been Tested For
Cannabis for neurodegenerative disease is one claim in public and four separate evidence bases in the literature, with randomized trials in Parkinson's disease, dementia, Huntington's disease, and motor neuron disease pointing in different directions.…
Which Genes Actually Change How You Respond to Cannabis, and Which Ones Are Being Oversold
Cannabis pharmacogenetics has produced one solid result and a long tail of associations that consumer testing companies treat as though they were equally established. The documented finding is that CYP2C9*3 homozygotes reach roughly three times the THC…
The Oil Outgrew the Hardware: Inside Cannabis Vape’s Materials Reckoning
✦ New CED Clinical Relevance #67 Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. SleepAnxietyNeurologySafetyDosingIndustryResearch Why This Matters This article matters for clinicians and their patients as it…
Bertha madras on X
✦ New CED Clinical Relevance #67 Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. THCNeurologyDosingSafetyResearchPolicyPain Why This Matters This article matters for clinicians and their patients as it…
CANNABIS use outside of what is medically prescribed, including recreational purposes, is …
✦ New CED Clinical Relevance #67 Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. PolicyMental HealthNeurologySafetyResearchPainAnxiety Why This Matters This article matters for clinicians and their patients as…
U.S. Supreme Court Asked Whether Expunged Missouri Marijuana Conviction Can Still …
✦ New CED Clinical Relevance #70 Notable Clinical Interest Emerging findings or policy developments worth monitoring closely. PolicyNeurologyCBDResearchMental HealthHempSafety Why This Matters This article matters for clinicians and their patients as it…
