A new protocol outlines development of brief cannabis intervention emergency department approaches for assault-injured young adults. This early-stage research addresses co-occurring alcohol and cannabis use in emergency settings. The protocol represents intervention development rather than proven clinical outcomes.
Randomized and Blind Evaluation of the Efficacy of a Full-Spectrum Oral
A randomized controlled trial found that full-spectrum cannabis extract provided significant pain relief for dogs with chronic osteoarthritis compared to placebo. This cannabis osteoarthritis clinical trial adds controlled evidence supporting cannabinoid analgesic effects in degenerative joint disease. The findings warrant further investigation in human osteoarthritis populations.
IBS Clinical Care Gaps and the Potential of Future Therapeutics based on Peripheral Visceral Afferent Modulation.
A comprehensive review identifies peripheral visceral afferent modulation as a promising but clinically unproven approach to address the greatest unmet need in IBS care: safe and effective pain management. While mechanistically rational, translation from rodent models to human therapeutics remains the critical next step.
Detection of ฮ9-Tetrahydrocannabinol Impairment Using Resting-State Functional Near-Infrared Spectroscopy: A Randomized Clinical Trial.
A randomized trial found that functional near-infrared spectroscopy (fNIRS) accurately detected THC impairment with superior performance compared to traditional field sobriety tests. This neuroimaging approach offers an objective method for impairment detection that could transform cannabis safety protocols, though practical implementation challenges remain.
Reducing severe breathlessness with dronabinol in the group of patients with severe and very severe chronic obstructive pulmonary disease (BONG): a randomised, double-blinded, placebo-controlled, crossover study in an outpatient clinic in Denmark
A new randomized crossover trial will investigate whether dronabinol COPD breathlessness treatment can help patients with severe symptoms. This protocol review examines the study design and clinical context for cannabis medicine in respiratory care.
Does oral cannabidiol oil in adjunct to pain medications help reduce pain and improve locomotion in dogs with osteoarthritis?
A systematic review of four clinical trials suggests CBD oil for dog osteoarthritis pain relief may provide modest benefits when added to conventional medications, though researchers characterize the current evidence quality as weak, indicating more rigorous studies are needed before definitive clinical recommendations.
Insights Into Cannabis and Cannabinoids: Chemical Properties, Legal Perspectives, and Therapeutic Applications.
Cannabis sativa L. has been used for thousands of years in various cultural, medical, and industrial settings. This review brings together evidence from hist…
Comparative Pharmacokinetics and Safety of Cannabidiol in a Powder Formulation, CBtru
A Phase I trial demonstrates that CBD powder formulation pharmacokinetics match oil-based products in healthy adults. The study reveals formulation-dependent food effects on absorption. While bioequivalence is established, clinical advantages remain unproven.
Higher THC Concentration Medicinal Cannabis Products Efficacy and Safety Considerations: A Rapid Review.
A rapid review of 15 studies examining higher THC medicinal cannabis efficacy and safety found therapeutic benefit for chronic pain and PTSD, but confirmed increased risk of cognitive and psychiatric adverse effects. This evidence provides important clinical guidance for prescribing higher THC medicinal cannabis products in appropriate patient populations.
Analgesic Effect of Cannabinoids for Fibromyalgia: A Systematic Review and Meta-Analysis.
A systematic review and meta-analysis found that cannabinoids for fibromyalgia pain relief show measurable analgesic benefits across randomized trials. This evidence supports considering cannabinoids as a potential treatment option for fibromyalgia patients experiencing inadequate pain control with conventional therapies.