What the Liver Does to an Edible Before You Feel Anything
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September 4, 2026
When cannabis is swallowed, the liver converts a large share of the THC into 11-hydroxy-THC before it ever reaches the brain, which is why edibles are slow to start and long to finish. Controlled human studies put blood concentrations of THC and…
Why the Same THC Dose Behaves Differently at 30 and at 70
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September 4, 2026
Cannabis pharmacokinetics in older adults rests on a thinner evidence base than most clinical discussion suggests, with the only controlled trial in adults over 65 enrolling twelve people. Route of administration shifts the balance between THC and its…
The Last Step of THC Metabolism: What Glucuronidation Explains About Drug Tests and Drug Interactions
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September 4, 2026
THC glucuronidation is the phase II step that attaches a sugar to oxidized THC metabolites and makes them water soluble enough to excrete. It explains why urine testing detects a conjugated acid metabolite rather than THC, and why only about 2 to 3…