The average bioavailability of CBD and THC is identified as 31% when smoked/inhaled, significantly higher than the bioavailability of the oral route, with reported absolute oral bioavailability typically ranging from approximately 6–10% for THC and 6–19% for CBD.
Can Oral Mucosal Delivery Unlock Cannabinoid Medicine’s Potential?
Oral mucosal drug delivery systems offer a viable alternative by enabling transmucosal absorption, bypassing hepatic metabolism, and facilitating both rapid and sustained drug release.
Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement.
Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) have garnered significant interest for their broad-spectrum pharmacological activity in…
Cannabinoid Oral Mucosal Delivery: Approaches to Formulation, Fabrication, and Permeation Enhancement.
Cannabinoids such as cannabidiol (CBD) and tetrahydrocannabinol (THC) have garnered significant interest for their broad-spectrum pharmacological activity in…